DJOSET

Active material: Salbutamol, Bromgeksin, Guaifenesin, menthol
When ATH: R05CB10
CCF: The drug with mucolytic, bronchodilator and expectorant action
ICD-10 codes (testimony): A15, J04, J15, J20, J37, J42, J43, J44, J45, J63
When CSF: 12.01.06.01
Manufacturer: UNIQUE PHARMACEUTICAL Laboratories (India)

Pharmaceutical form, composition and packaging

Syrup orange.

	5 ml
salbutamol sulphate	1.205 mg,
that corresponds to the content of salbutamol	1 mg
Bromhexine hydrochloride	2 mg
guaifenesin	50 mg
menthol (levomenthol)	500 g

Excipients: Sodium methyl parahydroxybenzoate, sodium propyl parahydroxybenzoate, sucrose, propylene glycol, sodium saccharin, sorbic acid, glycerol, citric acid monohydrate, sorbitol (noncrystallizing) liquid, colorant sunset yellow, Purified water.

100 мл – флаконы темного стекла (1) в комплекте с мерным стаканчиком – пачки картонные.
100 мл – флаконы из темного полиэтилентерефталата (1) в комплекте с мерным стаканчиком – пачки картонные.

Pharmacological action

Combined preparation, It has a bronchodilator, expectorant, mucolytic action.

Сальбутамол – бронхолитическое средство, стимулирует b₂

-adrenergic receptors of the bronchi, prevents or relieves bronchospasm.

Бромгексин – муколитическое средство, It has expectorant and antitussive effect of the weak. Reduces the viscosity of sputum by depolarization acid mucopolysaccharides and stimulation of secretory cells of the bronchial mucosa. It activates the cilia of ciliated epithelium, improving expectoration.

Гвайфенезин – уменьшает поверхностное натяжение и адгезивные свойства мокроты, increases serous component of bronchial secretions, reduces the viscosity of sputum, activates the ciliary apparatus of the bronchi, It facilitates the removal of phlegm and facilitates the transition of non-productive cough productive.

Ментол – оказывает спазмолитическое действие, gently stimulates the secretion of bronchial glands, It has antiseptic properties, okazyvetsya a calming effect and reduces the irritation of the respiratory tract.

Pharmacokinetics

Information about the pharmacokinetics of the drug is not provided.

Testimony

Acute and chronic bronchopulmonary diseases, accompanied by obstruction of sputum discharge:

- Bronchial asthma;

- Chronic bronchitis;

- Emphysema;

- COPD;

- Traheobronhit;

- Pneumonia;

- Pneumoconiosis;

- Pulmonary tuberculosis.

Dosage regimen

The drug is taken orally.

Children under 6 years - By 1 no. l. (5 ml) 3 times / day; from 6 to 12 years - by 1-2 no. l. (5-10 ml) 3 times / day.

Adults and children over 12 years - By 2 ch.l. (10 ml) 3 times / day.

Side effect

CNS: headache, dizziness, increased nervous irritability, sleep disturbance, drowsiness, tremor, convulsions.

From the digestive system: nausea, vomiting, diarrhea, aggravation of gastric ulcer and duodenal ulcer; очень редко – повышение активности печеночных трансаминаз.

Cardio-vascular system: tachycardia, decrease in blood pressure, collapse.

From the urinary system: Urine staining pink.

Allergic reactions: skin rash, hives, paradoxical bronchospasm.

Contraindications

- Dryness;

- Miokardit;

- Aortalnыy stenosis;

- Dekompenirovanny diabetes;

- Thyrotoxicosis;

- Glaucoma;

- Liver and / or kidney failure;

- Gastric ulcer and duodenal ulcer in the acute phase;

- Gastric bleeding;

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

FROM caution must be use in patients with diabetes, hypertension, gastric ulcer and duodenal ulcer in the anamnesis; simultaneously with antitussive, неселективными блокаторами b-адренорецепторов, MAO inhibitors.

Pregnancy and lactation

Do not use this drug during pregnancy and lactation (breast-feeding).

Cautions

Gvayfenezin urine stains in pink.

It is not recommended to wash down medication alkaline drinking.

Overdose

Symptoms: increasing incidence of side effects.

Treatment: simptomaticheskaya therapy.

Drug Interactions

Beta₂-adernomimeticheskie funds, Theophylline and other xanthine, while the use of drugs increases the risk of tachyarrhythmias.

MAO inhibitors and tricyclic antidepressants increase the effect of salbutamol, can lead to a sharp decrease in blood pressure.

Diuretics and corticosteroids enhance the hypokalemic effect of salbutamol.

The simultaneous use of drugs, containing codeine, and other antitussives difficult attenuated sputum expectoration.

Part of the preparation Bromhexine promotes the penetration of antibiotics into the lung tissue.

Not recommended for use in conjunction with non-selective blockers, β-adrenergic.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children at or above 30 ° C. Shelf life - 3 year.