Guaifenesin
When ATH:
R05CA03
Pharmacological action
Expectorant. It reduces surface tension and adhesion properties of sputum, It is reducing its viscosity and facilitates evacuation of respiratory ways.
Guaifenesin possesses anxiolytic effects.
Pharmacokinetics
Rapidly absorbed from the gastrointestinal tract (through 25-30 minutes after ingestion). It penetrates tissue, containing acid mucopolysaccharides. It is metabolized in the liver. T1/2 – 1 no. Return with phlegm through the lungs and the kidneys as inactive metabolites.
Testimony
Symptomatic treatment of diseases of the upper respiratory tract, accompanied by productive cough.
In the combined therapy: neurotic state, symptoms of dystonia neurocirculatory.
Dosage regimen
Individual, depending on the evidence, the dosage form employed and the age of the patient.
Side effect
From the digestive system: nausea, vomiting, gastralgia, abdominal pain, diarrhea.
CNS: dizziness, headache, drowsiness.
Allergic reactions: skin rash, hives, hyperthermia.
Contraindications
Wet cough with copious phlegm, gastric ulcer or duodenal ulcer, gastrorrhagia (history), Children up to age 2 years (efficacy have not been studied), hypersensitivity to guaifenesin.
Pregnancy and lactation
During pregnancy and lactation guaifenesin should be used with caution, Only in cases, when the expected therapeutic benefit to the mother outweighs the potential risk to the fetus or infant.
Cautions
Caution should be exercised when used in children aged 2 to 12 years with persistent or chronic cough in the background of asthma or increased sputum (Before the appointment of guaifenesin requires careful medical supervision).
During treatment, it is recommended to take plenty of fluids. It is advisable to combine with postural drainage and vibration massage of the thorax.
Perhaps staining of urine in pink.
Determination results of 5-HIAA in urine (in ispolyzovanii nitrozonaftolynogo reagent) It may be falsely inflated due to the influence of metabolites of guaifenesin per color (reception should be stopped for guaifenesin 48 h to collect urine for the test).
Guaifenesin and its metabolites may cause discoloration in determining vanillylmandelic acid in urine and falsely inflate test results with her catechins (reception should be stopped for guaifenesin 48 h to collect urine for the test).
Drug Interactions
With simultaneous use of guaifenesin increases the effect of funds, providing a depressing effect on the central nervous system, and ethanol.
