Amlodipine

When ATH:
C08CA01

Characteristic.

Derived digidropiridina-calcium antagonist II generation. The white crystalline powder, slightly soluble in water, sparingly soluble in ethanol.

Pharmacological action.
Antianginalnoe, gipotenzivnoe, vazodilatirtee, antispasmodic.

Application.

Arterial hypertension (monotherapy or in combination with other hypotensive drugs), stable and vazospastical stenocardia (Princmetala), incl. patients, resistant to therapy with nitrates or beta-adrenoblokatorami.

Contraindications.

Hypersensitivity (incl. other digidropiridinam), hypotension (less 90 mm Hg. Art.), shock, acute myocardial infarction (incl. period 1 months thereafter).

Restrictions apply.

Unstable angina, vыrazhennыy aortalnыy stenosis, heart failure, abnormal liver function, Age to 18 years (Safety and efficacy have not been determined).

Pregnancy and breast-feeding.

Perhaps during pregnancy, if the effect of therapy outweighs the potential risk to the fetus.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

At the time of treatment should stop breastfeeding.

Side effects.

Cardio-vascular system and blood (hematopoiesis, hemostasis): facial flushing, heartbeat; rarely — rhythm (bradycardia, ventricular tachycardia, auricular flutter), chest pain, gipotenziya (incl. orthostatic).

From the nervous system and sensory organs: fatigue, headache, dizziness, drowsiness; rarely fatigue, asthenia, mood changes, visual disturbances.

With the genitourinary system: peripheral edema (swelling of the ankles and feet); rarely, an increase in the frequency of urination, impotence.

From the digestive tract: nausea, abdominal pain; seldom-neuralgia, change of bowel movements, jaundice.

From the respiratory system: rarely — shortness of breath.

On the part of the musculoskeletal system: seldom-artralgia, myalgia, paresthesia and pain in the limbs (prolonged use).

For the skin: rashes, itch, rarely mnogoformnaya Erythema.

Other: rarely giperplazia gums, gynecomastia, elevated liver enzymes.

Cooperation.

Compatible with major groups gipotenziveh funds (Diuretic, ACE inhibitors, beta-blockers), nitrates and gipoglikemicakimi drugs. Means for inhalation anesthesia (hydrocarbon derivatives), Amiodarone, quinidine and other calcium antagonists (may exacerbate the effects). NSAIDs (especially indomethacin) reduce gipotenzivny effect (inhibit prostaglandin synthesis in the kidneys and natrillurez).

Overdose.

Symptoms: chrezmernaya perifericheskaya vasodilation, expressed and prolonged reduction in ad, tachycardia.

Treatment: gastric lavage, appointment of activated carbon, giving patients the horizontal position with pripodnatami feet, monitoring the performance of the heart and lungs, control and Bcc diureza; symptomatic and supportive therapy, in / in a liquid, Calcium Gluconate, dopamine, phenylephrine. Hemodialysis is not effective.

Dosing and Administration.

Inside, initial dose is 2.5-5 mg 1 once a day, the usual dose is 5 mg per day, If necessary, the dose can be gradually increased to a maximum of- 10 mg 1 once a day.

Precautions.

Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention (early treatment possible dizziness and drowsiness).

Cooperation