Tamsulozin
When ATH:
G04CA02
Characteristic.
White crystals. Poorly soluble in water and methanol, little soluble in glacial acetic acid and ethanol, practically insoluble in ether.
Pharmacological action.
Antidizuricescoe, Alpha adrainoliticescoe.
Application.
Functional symptoms, incl. violation of urination, in benign prostatic hyperplasia.
Contraindications.
Hypersensitivity, ortostatical gipotenzia in history, severe liver and / or kidney failure.
Side effects.
From the nervous system and sensory organs: 5-20% of dizziness, headache, asthenia; less 5% -drowsiness/insomnia.
Cardio-vascular system and blood (hematopoiesis, hemostasis): less 5% - Orthostatic hypotension.
With the genitourinary system: retrograde ejaculation (8,4%); less 5% — decrease libido.
Other: 5-20% of back pain, rhinitis, diarrhea; less 5% -chest pain, nausea.
Cooperation.
The simultaneous use of other alpha1-adrenergic can lead to increased gipotenzivnogo effect. Zimetidin increases, and furosemide reduces the concentration in the blood, diclofenac and warfarin increase the speed out.
Overdose.
Symptoms: possible acute hypotension.
Treatment: giving patients lying position, introduction of plasma substitutional solutions or sossoudossoujiwath drugs; to stop suction-gastric lavage, administration of activated charcoal or osmotic laxative.
Dosing and Administration.
Inside (After breakfast, drinking plenty of water), by 0,4 mg / day.
Precautions.
Before treatment to verify diagnosis (to exclude a carcinoma of the prostate).
Be wary when susceptibility to orthostatic hypotension, expressed human liver and Cl creatinine below 10 ml / min. When signs of orthostatic hypotension (dizziness, weakness) patient recommended seat or stow.
Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.
Cooperation
Active substance | Description of interaction |
Warfarin | FKV. Increases the rate of excretion. |
Diclofenac | FKV. Increases the rate of excretion. |
Prazosin | FMR. Against the backdrop of tamsulosin amplified gipotenzivny effect and increased risk of orthostatic hypotension; concomitant use is not recommended. |
Terazosin | FMR: synergism. Against the backdrop of tamsulosin may have significant increased gipotenzivnogo effect; concomitant use is not recommended. |
Furosemid | FKV. Speeds up excretion, several lowers (C)max и AUC. |