Psoraleya kostyankovaya – Psoralea drupacea
Perennial herb up to 1-1.5 m, leguminous (Fabaceae). It grows in the southern regions, mostly in Central Asia. Harvest fruits and roots of plants, of which is made drug "psoralen". In the native form psoraleya kostyankovaya in medical practice is not used.
Psoraleya kostyankovaya – Chemical composition
In fruits and roots contain psoralen kostyankovoy furokumariny psoralen and izopsoralen, stimulate pigment formation of the skin upon irradiation with ultraviolet rays.
Psoraleya kostyankovaya – Pharmacological properties
Psoralen, as well as beroksan and ammifurin, It has photosensitizing properties. In its photosensitizing activity of psoralen and inferior beroksanu Ammifurin, but somewhat superior therapeutic efficacy meladinina.
Psoralen is characterized by relatively low acute toxicity and insignificant influence of the drug on the cardiovascular system and organs with smooth muscles. However, data are available about the presence of psoralen significant hypoglycemic properties.
Psoraleya kostyankovaya – Use in medicine
Basically psoralen prescribed for alopecia and baldness total, vitiligo in conjunction with exposure to ultraviolet. Side effects and contraindications are similar to those in the application ammifurina (IMMI Bolshaya) and beroksana (Parsnip).
Psoraleya kostyankovaya – Formulations, Dosing and Administration
Psoralen (Рsoralen) Assign into adults 0,005; 0,01 or 0,02 g daily 2-3 times a day 30 minutes before eating.
Daily dose: for adults - 0.04-0.06 g, Children under the age of 5 years - 0,005 g, from 5 to 10 years - 0,01 g, from 10 to 13 years - 0,015 g, from 13 to 16 years - 0,02 g. Along with oral or smeared depigmented patches of skin devoid of hair 0,1 % solution of the drug daily or every other day, overnight or for 2-3 hours prior to irradiation.
The duration of treatment 3-3,5 months. If necessary, designate refresher courses (2-3 Courses) intervals between 1-1.5 months-
Producing psoralen powder, tablets 0,01 and g 0,01 % solution 70 % alcohol for external use.
