Parsnip-Pastinaca sativa L.

The two-year herbaceous plant up to 1.5-2 m, Family selydereynыe (Apiaceae). Pasternak is cultivated as vegetable plants. For medical purposes, harvest the fruits of plants.

Parsnip seed – Himchesky composition

The fruits contain a number of parsnip furokumarinovyh connections. Pastinatsin refers to a series of heterocyclic compounds furokumarinovogo. Beroksan consists of two furokumarinov - bergaptena and ksantotoksina.

Parsnip – Pharmacological properties

The native form parsnip in medical practice is not used, and pharmacological properties of the plant is essentially determined contained therein bergaptenom and ksantotoksina. Extracted from plants pastinatsin refers to moderate antispasmodic drugs. In its application in laboratory animals has been a marked expansion of peripheral vessels and vessels of the heart, and also there is relaxation of smooth muscles of the uterus and intestines. After administration of the drug has been some calming influence on the activity of the central nervous system pastinatsina. By the nature of the pharmacological action pastinatsin very close to daukarinu and kellinu.

Beroksan is typical photosensitizing agent. With its indoor and outdoor applications marked a clear sensitization of the skin to ultraviolet radiation. Besides, beroksan also possesses some inflammatory properties, characteristic of the members of the group furokumarinov. With its internal use there is a marked vasodilator effect, especially in relation to coronary and peripheral vessels, However, authorities from the smooth muscles drug acts rather weakly.

Parsnip – Use in medicine

Pastinacin is used as an antispasmodic agent for angina pectoris, cardioneurosis and neuroses, accompanied koronarospazm, mainly as a prophylactic measure. Pastinatsin also used for spasms of the gastrointestinal tract, biliary- ing ways, kidney and ureter.

Application in medical practice based on its beroksana expressed photosensitizing properties and ability to stimulate the formation of melanin pigment skin layers under the action of certain portions of the ultraviolet spectrum of light rays. Beroksan used in conjunction with ultraviolet radiation in Psoriasis, vitiligo, gnezdnom total alopecia, as well as other skin diseases.

Beroksan applied in the Interior in the form of tablets and externally as a solution for rubbing. Inside appoint 0,02 g (1 tablet) appointment. Take from 1 to 4 time (depending on individual sensitivity and season of the year) by 1 tablet for 4-3-2, and 1 h before irradiation. The course consists of 4-6 cycles with breaks in between 15-20 days. The total dose of treatment for adults is 250-300 tablets. Children over 5 years receive 1 / 3-1 / 2 rate adult depending on the age.

Along with taking the drug inside beroksana rubbing solution in the lesions, followed by irradiation of ultraviolet rays. Massaging is done at the beginning of the 12 and 8 h before irradiation (overnight), in subsequent cycles - for 4-2 1 h before irradiation. In pockets of vitiligo or alopecia baldness evenly rubbed a finger in a rubber glove or fingertip 0,5 % solution beroksana, pre-applied to the pockets of the pipette. Not allowed to wash with water to these pockets of exposure. If you notice an increased sensitivity of the skin to 0,5 % its diluted solution beroksana 70 % alcohol against 1:4, 1:3 and t. d. Just over the cycle is 10-20 rubbing and exposures. Exposure mode patient mercury-quartz lamp set, based on the data of the preliminary determination biodozy. These rules must be observed treatment as the application of beroksana for the treatment of psoriasis by photochemotherapy.

In the absence of the desired effect, a treatment repeated, by -2 months. In the summer months in order to avoid actions summed artificial and natural ultraviolet radiation is recommended to combine the use of a fractionated radiation beroksana sunlight.

The most pronounced effect in the treatment of drug observed in young patients, with a small duration of the disease, from brunettes and individuals, prone to sunburn.

Beroksanom Treatment should be under close medical supervision. In applying the drug could experience side effects (headache, heartbeat, precordialgia, dyspeptic symptoms), which decrease or disappear at lower dose or a temporary break in treatment.

It should warn patients of the possibility of the development of bullous dermatitis when combined exposure lesions mercury-quartz lamp and the sun. It should adhere strictly to the irradiation of mercury-quartz lamp or the sun.

Beroksan contraindicated for hypertension, tuberculosis, thyrotoxicosis, blood diseases, liver diseases, kidney, hearts, CNS. Not recommended for children younger than appoint him 5 years and older persons 50 years.

Parsnip – Formulations, Dosing and Administration

Pastinacin taken orally in tablets 0,02 g (20 mg) 2-3 Times a day (before meals). The course of treatment 2-4 weeks.

Beroksan - White to yellowish white crystalline powder;. Practically insoluble in water, slightly soluble in alcohol, easy - in chloroform.

Apply beroksan inside in the form of tablets and externally as a solution for rubbing. Together with the admission of the drug inside beroksana solution is applied to the lesions of the skin with subsequent irradiation their ultraviolet rays.