IMMI Bolshaya – I loved him more

Annual herb up to 50-60 cm, families zontichnыh (Apiaceae). For medical purposes, harvest the fruits of Ammi majus, of which is made ammifurin. In the native form of the plant not used.

IMMI Bolshaya – Chemical composition

The fruits of Ammi majus found highly furokumarinovye compounds and other chemicals. The greatest value for medicine are furokumariny bergapten, xanthotoxin and izopimpinellin.

IMMI Bolshaya – Pharmacological properties

Biological activity bergaptena, xanthotoxin and izopimpinellina, contained in the plant, determined by the pharmacological properties of Ammi majus. Ammifurin, consisting of the sum of these furokumarinov, It refers to a group of drugs photosensitizing action. As drug beroksan, Dedicated parsnip seed, ammifurin photosensitizing and has a spasmolytic activity.

In the study of the properties of obschefarmakologicheskih ammifurina failed to reveal significant antispasmodic effect of the drug on organs with smooth muscles. Ammifurin at local and resorptive action does not significantly affect blood pressure, frequency and rhythm of breathing and heart activity. The drug has a relatively low acute toxicity. Irritant properties not found.

Ammifurin increases the skin's sensitivity to light radiation and stimulates the production of melanin pigment in it under the influence of ultraviolet rays, that helps to restore skin pigmentation in a number of skin diseases.

IMMI Bolshaya – Use in medicine

Ammifurin prescribed to patients to restore skin pigmentation in vitiligo in conjunction with ultraviolet radiation dosage. The drug is also used for psoriasis, nesting and total baldness. In the treatment of baldness Ammifurin in combination with propolis preparations noted the high therapeutic efficacy. During the course of treatment only in selected patients had nausea, dizziness, and discomfort in the abdomen.

In the treatment of baldness ammifurin exceeds the activity of the drug meladinin, and in the treatment of psoriasis and other skin diseases by photochemotherapy drug is not inferior to other photosensitizing agents.

For the treatment of vitiligo, alopecia, and total alopecia ammifurin administered in tablets 0,02 g daily, 3-4 times a day before meals and for 4-3-2 1 h before irradiation. Simultaneously for 1 h before irradiation skin lesions smeared 0,3 % solution ammifurina. The course of treatment consists of 4-5 cycles with breaks in between 2-3 weeks. The duration of treatment 3-W,5 Months. Total dose for a course of treatment - 250-300 tablets. Children over 5 years receive 1/3 or 1/2 treatment of adult depending on the age. Patients older 50 years, the drug is not recommended.

Duration of irradiation is 1-2 minutes initially with a gradual increase up to 15-20 minutes, depending on the individual patient's sensitivity to ultraviolet rays. In the summer of irradiation quartz lamp can be replaced by solar insolation.

For the treatment of psoriasis by photo chemotherapy ammifurin designate the interior of 1-1.5 per pill 2 C to UFO and 1 h before irradiation lubricate affected areas 0,3 % solution ammifurina. Total for one cycle is 10-20 rubbing and exposures. In the overall treatment of psoriasis by photochemotherapy for a year requires 300-400 tablets and 50-80 exposures longwave ultraviolet lamp. Treatment is not recommended for children.

IMMI Bolshaya – Side effects and contraindications

Nausea, dizziness, which disappear after canceling ammifurina. When combined with radiation lesions mercury-quartz lamp and solar radiation may develop bullous dermatitis. In this case, the treatment should be discontinued until the complete disappearance of side effects.

Ammifurin contraindicated in lupus, blood diseases, liver, kidney, cardiovascular and CNS.

IMMI Bolshaya – Formulations, Dosing and Administration

Ammifurin - Light yellow or light yellow with a greenish tinge crystalline powder. Practically insoluble in water, slightly soluble in alcohol, easy - in chloroform.

Administered orally as tablets and topically as a solution for rubbing. Inside appoint 0,02 g (by 1 tablet) appointment; take the morning of 1 to 4 time (depending on individual sensitivity and season of the year) by 1 tablet for 4-3-2, and 1 h before irradiation. The course consists of 4-6 cycles with breaks in between 15-20 days.

Along with taking the drug inside ammifurin applied to the lesions of the skin, followed by irradiation of ultraviolet rays.

Ammifurin available in tablets of 0,02 d in the vial after 50 pcs, as well as 0,3 % solution in vials.