Metronidazol (When ATH A01AB17)

Characteristic

White or slightly greenish crystalline powder. It is soluble in water and insoluble in alcohol.

Pharmacological action.
Antibacterial, protivoprotozoynymi, trihomonatsidnoe, protivoyazvennoe, antialcoholic.

Application.

Ameʙiaz, trichomoniasis, giardiaz, giardiasis, intra-abdominal infections (peritonitis, abscess), anaerobic infections of bones and joints, skin and soft tissue, female genital mutilation (endometritis, tubo-ovarian abscess), CNS (meningitis, brain abscess), lower respiratory tract (pneumonia, empyema, lung abscess), endokardit, psevdomembranoznыy colitis, éradikaciâ Helicobacter pylori, Saint Martin's evil, prevention of postoperative anaerobic infections. For external and local application: pink and acne vulgaris, bacterial vaginosis, nonhealing wounds, sores.

Contraindications.

Hypersensitivity (incl. to other nitroimidazole derivatives), pregnancy, lactation, childhood (except in cases of amoebiasis).

Restrictions apply.

Liver disease in violation of its functions (cumulative effect is possible), central and peripheral nervous system.

Side effects.

Nausea, vomiting, abdominal pain, diarrhea, an unpleasant metallic taste, headache, dizziness, syncope, ataxia, disturbances of consciousness, seizures, neutropenia (leukopenia), erythematous rash, itching, staining of urine a dark color, allergic reactions, tromboflebit (After i / v administration).

Cooperation.

Proximity effect anticoagulants and lithium salts. Phenytoin and phenobarbital snizhayut action (by activation of the liver microsomal system and accelerate metabolism and excretion), and cimetidine increases (inhibits the enzymatic system of the liver and, Consequently, slows the biotransformation). Incompatible with alcohol (by sharing a syndrome develops antabuspodobny).

Overdose.

Symptoms: nausea, vomiting, ataxia, in severe cases, peripheral neiropatia and epileptic seizures.

Treatment: symptomatic; there is no specific antidote.

Dosing and Administration.

Inside, during or after a meal. Ameʙiaz: adults-to 600-800 mg 3 twice a day during 8-10 days; children-35-50 mg/kg/day, in 3 receiving within 8-10 days.

Giardiazis: 15 mg / kg / day, in 3 reception within 5 days.

Trichomoniasis: adults-inwards, by 400 mg 2 times a day for 5-8 days (if necessary, repeat the course in 4-6 weeks) or once 2,0 or g 250 mg 2 twice a day for 10 days; the simultaneous treatment of both partners. Babies: 2-5 years - 250 mg / day, 5-10 years-250-375 mg/day, senior 10 years - 500 mg/day inwards, Thus, the daily dose is divided into 3 admission.

Giardiasis: adults - 400 mg 3 twice a day for 5 days or 250 mg 2 twice a day for 10 days; children: 2-5 years - 250 mg / day, 5-10 years-250-375 mg/day, senior 10 years - 500 mg/day inwards, in 3 admission. After completion of treatment 2-3 months control study carried out in the fullness of healing.

Helicobacter pylori eradication: by 500 mg 3 twice a day for 7 days, optionally combined with other. preparations.

Anaerobic infection: adults - 400 mg 3 twice a day for 7-10 days; Children up to 12 years - 7,5 mg / kg 3 once a day.

In severe cases, the drug is administered parenterally (/ drip) adult 500 mg 100 mL of solvent, children - a rate 7,5 mg/kg in the same amount of solvent. Infuziu spend with speed 5 mL/min intervals 8 no.

For the prevention of postoperative anaerobic infections: in day 1 after surgery — 1 g drug once, later on 200 mg 3 twice a day for 7 days.

Saint Martin's evil: inside, by 0,5 g / day for 6 (no more) months.

Intravaginal: 500 mg at night for 10 days.

Outwardly: apply 2 once a day, Dose set individually.

Cooperation