Cefepime (When ATH J01DA24)

When ATH:
J01DA24

Characteristic.

The antibiotic cephalosporin IV generation.

Zefepima hydrochloride is powder white or bledno-jeltogo color, soluble in water.

Pharmacological action.
Antibacterial, bactericide.

Application.

Respiratory Infections (including pneumonia, bronchitis) and urinary tract infections (incl. pyelonephritis), skin and soft tissue, abdomen (including as peritonitis, biliary tract infections), gynecological; septicemia, infection are immunocompromised (febrile neutropenia), bacterial meningitis in children, prevention of infections for abdominal surgery.

Contraindications.

Hypersensitivity (incl. other beta-lactam antibiotics and L-arginine), Children up to age 2 Months (Safety and efficacy have not been established).

Restrictions apply.

Diseases of the digestive tract (incl. history), chronic renal failure.

Pregnancy and breast-feeding.

Application during pregnancy is possible only under medical supervision.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

To use caution during breastfeeding.

Side effects.

From the nervous system and sensory organs: headache, dizziness, asthenia, paresthesia, insomnia, anxiety, confusion, convulsions, change in taste, encephalopathy (in the absence of dose adjustment in patients with impaired renal function).

Cardio-vascular system and blood (hematopoiesis, hemostasis): tachycardia, breathlessness, peripheral edema, anemia, thrombocytopenia, leukopenia, neutropenia, pancytopenia, gemoliticheskaya anemia.

From the digestive tract: nausea, vomiting, diarrhea or constipation, abdominal pain, dyspepsia, colitis, incl. pseudomembranous, oropharyngeal candidiasis.

With the genitourinary system: vaginitis, impairment of renal function.

Allergic reactions: skin rash (incl. erythematous rash), itch, hives, fever, anaphylactoid reactions, positive Coombs test without hemolysis, eozinofilija, erythema multiforme exudative; rarely Toxic Epidermal Necrolysis.

Other: cough, sore throat, backache, increased perspiration, increased liver transferases, Alkaline phosphatase, Calcium, potassium phosphate, BUN and / or serum creatinine, total bilirubin, decrease in the concentration of phosphorus, decrease in hematocrit, increased prothrombin time, Local reactions: with a / in the introduction - phlebitis, When the/m-pain, inflammation.

Cooperation.

Increases nephro- and aminoglycoside ototoxicity, furosemide and other loop diuretics. Pharmaceutically compatible with sodium chloride solution, Glucose, sodium lactate, Ringer's lactate. It should not be administered in the same syringe with solutions of metronidazole, vancomycin, gentamicin, Tobramycin, Netilmicin.

Overdose.

Symptoms: encephalopathy, seizures in patients with renal insufficiency.

Treatment: dialysis and supportive therapy.

Dosing and Administration.

B / and / m. Dosage and route of administration depending on the sensitivity of microorganisms pathogens, severity of infection, and renal function in a patient. In / in the route of administration is preferable for patients with severe or life-threatening infections. Adults and children weighing more than 40 kg normal kidney function is 0.5-1 g (in severe infections up 2 g). B / (slowly, 3-5 min) or deep v/m at intervals 12 no (with heavy infections is through 8 no). The course of treatment 7-10 days or more. If the kidney function the dose adjusted according to creatinine clearance. Patients, dialysis, After each session, you must enter a booster dose, equal to the original.

For children 2 month maximum dose should not exceed the recommended dose for adults. The recommended dosing regimen for children weighing up to 40 kg in all the testimony is 50 mg / kg every 12 no, patients with nejtropeničeskoj fever and bacterial meningitis — every 8 no. The usual duration of treatment is 7-10 days; severe infections may require a longer treatment.

Precautions.

To use caution in patients with all forms of allergy to drugs (possible cross-allergy). When diarrhea should consider the possibility of pseudomembranous colitis.

Cooperation