Disulьfiram

When ATH:
V03AA01

Characteristic.

White poor yellowish greenish white crystalline powder. It is soluble in alcohol, practically insoluble in water, acids and alkalis.

Pharmacological action.
Antialcoholic.

Application.

Saint Martin's evil (relapse prevention, no therapeutic effect on other methods), hronicheskaya nikelevaya intoxication.

Contraindications.

Hypersensitivity, thyrotoxicosis, diabetes, pronounced cardiosclerosis, Atherosclerosis of cerebral vessels, before- and postinfarction state, aneurysm aortы, coronary insufficiency, hypertension stage II-III, cardiovascular disease decompensated, pulmonary tuberculosis with hemoptysis, bronchial asthma, severe emphysema, erosion of the stomach, liver disease and kidney, mental illness, epileptiform syndrome, polyneuritis, glaucoma, pregnancy.

Restrictions apply.

Age older 60 years, gastric ulcer and duodenal ulcer (in the acute phase), endartyeriit, previously transferred psychosis in patients receiving disulfiram.

Side effects.

Metallic taste in mouth, hepatitis, neuro-psychiatric disorders, headache, polyneuritis of lower limbs, itching, hives.

Cooperation.

Effects, incl. neurotoxic, increase tricyclic antidepressants (Amitriptyline), metronidazol, Isoniazid, decreases (reaction of alcohol) -Ascorbic acid. It reduces blood clotting on the background of indirect anticoagulants. Increases toxicity of phenytoin.

Overdose.

Manifested coma, collapse, various neurological events. Treatment of symptomatic.

Dosing and Administration.

Inside, / m and n / a. Dose selected individually, is, usually, 0,250.5 g / day. P / and / m implanted 8-10 Table.