Giosцina -in

When ATH:
A03BB01

Characteristic.

Semi-synthetic derivative of hyoscyamine - alkaloid, contained in the herb, peeling, durmane, Scopoli; Quaternary ammonium compound. White crystal powder, easily soluble in water, soluble in alcohol. Molecular weight - 440,38.

Pharmacological action.
Spasmolytic.

Application.

Spastic GI status, gall and urinary tract (počečnaâ how, želčnaâ how, cholecystitis, kišečnaâ how, pilorospazm, incl. in newborn), spastic dyskinesia biliary tract and gall bladder, gastric ulcer and duodenal ulcer in the acute phase (in the complex therapy), algomenorrhea, endoscopic diagnostic and functional studies of the digestive system (to relax the smooth muscles); delivery (to speed up the opening of the cervix).

Contraindications.

Hypersensitivity (incl. other belladonna alkaloids), zakrыtougolynaya glaucoma, myasthenia, megacolon.

Restrictions apply.

Suspected intestinal obstruction (incl. stenosis pryvratnyka), urinary tract obstruction (incl. prostate adenoma), propensity to tachyarrhythmias (incl. atrial tachyarrhythmia).

Pregnancy and breast-feeding.

When pregnancy is prescribed with caution, especially in the I trimester (cm. and "Application"). At the time of treatment should stop breastfeeding (cm. and "Side Effects").

Side effects.

From the nervous system and sensory organs: headache, drowsiness, weakness, excitation, irritability, sleep disturbance, amnesia, Parez akkomodacii, blurred vision, increased sensitivity of the eyes to light, aggravation of glaucoma.

From the digestive tract: dry mouth and throat, constipation, nausea and vomiting.

Other: dryness of the nasal mucosa and skin, decreased sweating, decrease the amount of milk in lactating women, tachycardia, difficulty urinating, allergic reactions, skin redness at the injection site.

Cooperation.

Antacids, antidiarrheal agents, containing kaolin or attapulgite, ketoconazole, metoclopramide - weaken anticholinergic effect, anticholinergics, and tricyclic antidepressants (Amitriptyline, clomipramine, imipramine, trimipramine et al.) - Increase. Hyoscine butylbromide increases the risk of tachycardia, called beta-adrenergic agents.

Overdose.

Symptoms: mydriasis and the absence of reaction to light, dryness of mucous membranes, hoarseness, difficulty weight management, tachycardia, hyperthermia, dermahemia, disturbance of consciousness, hallucinations, convulsions, alternating with CNS depression, cessation of breathing, paresis bowel and bladder.

Treatment: gastric lavage with activated carbon and then 15% Magnesium sulfate, diurez, Repeated administration of physostigmine (every 1 / 2-1 hours) or galantamine (every 1-2 hours), to eliminate intestinal paresis and tachycardia, the introduction of neostigmine, with moderate or severe excitation convulsions - Magnesium sulfate; in severe cases - sodium oxybate, or oxygen therapy, IVL; if difficult urination - bladder catheterization. Patients with glaucoma - instillation of pilocarpine, if necessary, systemic administration may holinomimetikov.

Dosing and Administration.

Inside, rectally, parenterally, Dose selected individually. Inside, adults and children over 6 years - 10-20 mg 3-5 times a day.

Rectal, 10-20 mg (1-2 Supp.) 3 once a day.

In acute conditions - I /, / m or n / a, adult on 20 mg 3-4 times a day; older children 6 years - the usual dose for adults. Children 3-6 years old - 10 mg 3-4 times a day; to 3 years - 5 mg 3-4 times a day.

Precautions.

It is necessary to take into account the significant differences of individual sensitivity to hyoscine, incl. the possibility of excitation, hallucinations while taking usual doses in individual patients. The risk of side effects is increased in the elderly. Prohibited use of alcohol during treatment. Avoid overheating when performing intense exercise and in hot weather, as well as hot tubs and saunas. During the period of treatment is not recommended driving and other activities, requiring higher reaction rate. To reduce dry mouth can use sugarless gum, small pieces of ice, Saliva substitutes. It should be taken into account, that persists for more than 2 weeks dry mouth increases the risk of diseases of tooth enamel, right, fungal infections. Cancel the drug should be carried out gradually (with rapid abolition may cause nausea, potlyvosty, dizziness).

Cooperation