Gastal

Active material: Gidrotalcit, Magnesium hydroxide
When ATH: A02AX
CCF: Antacids
ICD-10 codes (testimony): K21.0, K25, K26, K27, K29, K30, K44, K85, K86.1, R12
When CSF: 11.01.04
Manufacturer: PLIVA KRAKOW Pharmaceutical Company S.A. (Poland)

Pharmaceutical form, composition and packaging

◊ Pills white, round, with a flat and smooth surface and bevelled edges.

Excipients: mannitol, sorbitol, lactose, corn starch, sodium cyclamate, sodium saccharin, talc, magnesium stearate, peppermint flavor (Peppermint).

6 PC. – blisters (4) – packs cardboard.
6 PC. – blisters (5) – packs cardboard.
6 PC. – blisters (8) – packs cardboard.
6 PC. – blisters (10) – packs cardboard.

Pharmacological action

Combined antacid oral. It reduces the acidity of gastric juice to a physiological level and eliminates dyspeptic disorders by neutralizing excess hydrochloric acid in the stomach.

Included in the Gustav^® magnesium hydroxide and aluminum hydroxide provide fast and lasting neutralization, Determining the effect of antacid. Gastal^® It inhibits the action of pepsin, lysolecithin and bile acids, thus, and eliminating the disorders of the stomach.

Gastal^®, in addition to the antacid effect activates protective and regenerative mechanisms in the gastric mucosa. The cytoprotective effect, due to aluminum ions, It includes stimulation of mucus secretion and sodium hydrogen carbonate in the stomach, accumulation of epidermal growth factor in the focus of damage, increased concentration of phospholipids in the stomach and other mechanisms.

The antacid effect is manifested immediately after taking the pills Gastal^® and lasts for about 2 no. 1 tablet neutralizes about 21.5 mM hydrochloric acid.

Pharmacokinetics

The drug Gastal^® It is not absorbed when taken orally.

After reaction with hydrochloric acid of the gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and excreted with feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in the gastric juice to form a magnesium chloride, which has an osmotic laxative effect in the small intestine. Magnesium is also excreted in the feces as an insoluble carbonate.

Gastal^® It has no systemic effects in patients with normal renal function.

Testimony

- Heartburn (incl. after drug administration, alcohol, coffee, errors in feeding, the abuse of nicotine);

- State, accompanied by an increase of acid in the stomach: gastritis, gastric ulcer and duodenal ulcer;

- Symptomatic ulcers of different genesis;

- Erosion of the gastric mucosa of the upper gastrointestinal tract;

- Reflux esophagitis;

- Hiatal hernia;

- Acute pancreatitis, exacerbation of chronic pancreatitis (in a combination therapy);

- Brodilynaya or dyspepsia gnilostnaya (in a combination therapy).

Dosage regimen

The drug is taken orally. The tablet should be gradually dissolve (not swallowed whole).

Adults appoint 1-2 tab. 4-6 time / day, but not more than 8 tab. during 24 no. The drug is recommended to take over 1 hours after meals and at bedtime.

The maximum duration of the reception – 2 of the week.

At izžoge the drug is prescribed in the recommended doses, regardless of the meal.

In order to prevent Gastal^® apply to the alleged irritating effect on the gastrointestinal mucosa.

To children aged 6 to 12 years half the dose prescribed for adults.

Side effect

From the digestive system: rarely – nausea, vomiting, change in taste, diarrhea, constipation.

Other: rarely – allergic reactions.

Contraindications

-hronicheskaya Renal failure;

-Alzheimer's disease;

-gipofosfatemiya;

-Children Under the age of 6 years;

-Increased sensitivity to the drug.

FROM caution should use the drug in children under the age of 12 years; during pregnancy and lactation is possible only by the use of prescription and under supervision of a physician.

Pregnancy and lactation

Use of the drug during pregnancy and lactation (breast-feeding) possible only under medical supervision in cases, when the intended benefits to the mother outweighs the potential risk to the fetus.

Cautions

Patients with low body weight, and children over the age of 6 Gastal years^® should be used in lower doses and less prolonged.

In patients with renal impairment is not recommended Gastal^® doses, exceeding recommended, and for a longer time.

Continuous intake of more than 2 weeks is only possible in the appointment of a doctor.

Overdose

Not reported symptoms of acute overdose.

Symptoms: Chronic administration of high doses of drugs, containing aluminum and magnesium, may develop hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, gipermagniemii, giperalyuminiemiya, эncefalopatii, nephrocalcinosis and renal failure. Perhaps increased side effects from the digestive system (constipation, diarrhea). In patients with concomitant renal insufficiency may thirst, decrease in blood pressure, giporefleksiя.

Treatment: symptomatic therapy.

Drug Interactions

The interval between doses Gastal^® and other drugs should be 1- 2 no.

Gastal^® enhances the effect of levodopa and nalidixic acid.

At simultaneous application reduces and slows the absorption of tetracycline antibiotics, ciprofloxacin and ofloxacin, salitsilatov, izoniazida, naproxen, iron supplementation, cardiac glycosides, indomethacin, aminazina, phenytoin, blokatorov gistaminovyh N₁-receptors, beta-blockers, diflunizala, fat-soluble vitamins, anticoagulants, ʙarʙituratov.

M-holinoblokatory, slowing gastric emptying, reinforce and extend the action of the drug.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored in a dry, inaccessible to children at temperature not exceeding 25 ° C. Shelf life – 3 year.