Doksazozin

When ATH:
C02CA04

Characteristic.

White powder. Easily soluble in DMSO, soluble in dimethylformamide, it is soluble in methanol, ethanol, water, acetone, methylene chloride.

Pharmacological action.
Gipotenzivnoe, vasodilator, gipolipidemicescoe, antispasmodic.

Application.

Arterial hypertension (monotherapy and combination with other antihypertensive drugs), incl. isolated systolic hypertension in older men, hypertension and metabolic disorders, benign prostatic hyperplasia (as in obstructive disorders, and if there are signs of inflammation), hindered the flow of urine.

Contraindications.

Hypersensitivity, stenosis of the aortic and mitral valves, pulmonary embolism, severe liver, pregnancy, lactation, Age to 18 years.

Side effects.

Эффект «первой дозы» — гипотензия, dizziness, syncope (rarely); postural orthostatic hypotension (long-term treatment), swelling, tachycardia, arrhythmias, fatiguability, breathlessness, dizziness, headache, nervousness, irritability, abnormal sleepiness, blurred vision, rhinitis, xerostomia, abdominal discomfort, nausea, constipation, chest pain, cerebrovascular accident, urinary incontinence (rarely).

Cooperation.

Doxazosin increases the hypotensive effect of antihypertensive drugs. Estrogens, causing fluid retention, contribute to increased blood pressure. NSAIDs (especially indomethacin) may reduce the hypotensive effect of doxazosin. Doxazosin reduces the pressor effect of metaraminol, ephedrine. Blocking alpha-adrenergic effects of epinephrine, which can lead to severe hypotension and tachycardia. There were no adverse interaction with the simultaneous application of thiazide diuretics and doxazosin, furosemida, beta-blockers, BCC, ACE inhibitors, antibiotics, oral hypoglycemic agents, indirect anticoagulants and urikozuricheskih funds. Alcohol may exacerbate the adverse reactions.

Overdose.

Symptoms: severe hypotension, syncope.

Treatment: the patient should be given a horizontal position on the back, at the head of the body, в случае неэффективности — в/в инфузии и введение вазопрессорных препаратов.

Dosing and Administration.

Inside. Начинают лечение с 1 mg / day, single, gradually increasing (cherez 1-2 Sun) to 2 mg, затем до 4–8 мг. Максимальная суточная доза при доброкачественной гиперплазии предстательной железы — 8 mg, при артериальной гипертензии — 16 мг при однократном приеме.

Precautions.

It must be borne in mind, that the effect of the first dose is especially pronounced during therapy with diuretics, as well as a diet with restriction of sodium. Older people have lower dosage. When driving vehicles and work on the production should take into account the possibility of orthostatic hypotension, and decreased concentration and reaction speed (usually, at the beginning of treatment). Use caution with abnormal liver function (in case of deterioration of the functional state of the liver drug immediately overturned). Before therapy of benign prostatic hyperplasia is necessary to exclude its malignant degeneration.

Cooperation