Cefixime

When ATH:
J01DD08

Characteristic.

Semisynthetic cephalosporin antibiotic III generation oral.

Pharmacological action.
Antibacterial, bactericide.

Application.

Infectious-inflammatory diseases, caused by susceptible to malaria infections: pharyngitis, tonsillitis, sinusitis, acute and chronic bronchitis, otitis media, uncomplicated urinary tract infections, neoslojnennaya gonorrhea.

Contraindications.

Hypersensitivity.

Restrictions apply.

Children up to age 6 Months (Safety and efficacy have not been determined).

Pregnancy and breast-feeding.

When pregnancy is possible, if the effect of therapy outweighs the potential risk to the fetus (adequate and well-controlled studies of the safety of use in pregnant women were not conducted). In the study of reproduction in mice and rats at the doses administered to animals, to 400 times the human dose, There were no violations of the fetus.

At the time of treatment should stop breastfeeding (unknown, whether cefixime gets into breast milk).

Side effects.

From the nervous system and sensory organs: headache, dizziness.

From the hematopoietic system: eozinofilija, leukopenia, thrombocytopenia, neutropenia, gemoliticheskaya anemia.

From the digestive tract: stomatitis, diarrhea, nausea, vomiting, abdominal pain, psevdomembranoznыy colitis, transient increase in liver transaminases and alkaline phosphatase.

With the genitourinary system: increase of urea nitrogen or creatinine content in serum, described cases of interstitial nephritis.

Allergic reactions: skin rash, itch, hives, erythema multiforme, Syndrome Stevens - Johnson.

Other: genital mycosis, vaginitis, candidiasis.

Cooperation.

With simultaneous use of cefixime and carbamazepine increases the concentration of carbamazepine in plasma.

Overdose.

Symptoms: increased adverse reactions.

Treatment: gastric lavage, symptomatic and supportive therapy, incl. appointment of antihistamines and glucocorticoids, or oxygen therapy, IVL. In large quantities it is not displayed by hemo- or peritoneal dyalyza. Spetsificheskiy antidote unknown.

Dosing and Administration.

Inside, adults and children over the age of 12 years weighing more than 50 kg daily intake is on 400 mg (1 once a day or 200 mg 2 once a day). Children aged 6 Months before 12 years: by 8 mg/kg/day or 4 mg / kg every 12 no. The duration of treatment depends on the severity of the disease and is individually.

If the kidney function (When Cl creatinine 21-60 ml/min) or in patients, hemodialysis, the daily dose should be reduced by 25%. When Cl creatinine less than or equal to 20 mL/min or in patients, on peritoneal dialysis, the daily dose should be reduced 2 times.

Precautions.

Prior to cefixime therapy need to know, noted whether the patient last hypersensitivity reactions to cephalosporins, penicillins or other drugs. When used in penicillin-sensitive patients caution, tk. possible cross-hypersensitivity between beta-lactam antibiotics (It occurs in approximately 10% patients allergic to penicillin history). If you develop an allergic reaction to cefixime, Treatment should be discontinued. In severe acute hypersensitivity reactions may require administration of epinephrine and other emergency measures, including oxygen therapy, in / in a liquid, antihistamines (I /), corticosteroids, pressor amines, IVL.

Be wary appoint patients with any form of allergy, especially in the PM; patients with diseases of the gastrointestinal tract, especially colitis.

Chronic administration of the drug may impair the normal intestinal microflora, that can lead to growth Clostridium difficile and cause the development of severe diarrhea and pseudomembranous colitis.

In the application of cefixime may develop in the body deficiency of B vitamins.

During treatment, the likelihood of positive direct Coombs' test and false positive reaction to urinary glucose.

Cooperation