Цefamandol

When ATH:
J01DC03

Characteristic.

II generation cephalosporin antibiotic for parenteral administration.

Tsefamandola nafata - White, without smell, Crystals; soluble in water, methanol; practically insoluble in ether, xloroforme, benzene, ciklogeksane; solutions have a color from light yellow to amber (depending on the concentration and the solvent used), pH — 6,0–8,5; molecular weight 512,5.

Pharmacological action.
Broad-spectrum antibacterial, bactericide.

Application.

Infection: abdominal, gynecological, urinary tract infection, respiratory, bone and joints, skin and soft tissue, meningitis, sepsis, endokardit; burn infections, prevention of postoperative infectious complications.

Contraindications.

Hypersensitivity (incl. to other cephalosporins), natural infancy.

Restrictions apply.

Renal failure.

Pregnancy and breast-feeding.

Perhaps with caution in case of emergency, if the effect of therapy outweighs the potential risk to the fetus or infant.

Side effects.

Cardio-vascular system and blood (hematopoiesis, hemostasis): leukopenia, thrombocytopenia, neutropenia, gemoliticheskaya anemia; unusual bleeding or possible hemorrhage.

From the digestive tract: nausea, vomiting, abdominal pain, psevdomembranoznыy colitis, persistent hepatitis, cholestatic jaundice, transient increase in liver transaminases and alkaline phosphatase.

Allergic reactions: skin rash, hives, eozinofilija, drug fever, bronchospasm, angioedema, anaphylactic shock.

Other: headache, superimposed infection, dysbiosis, oral candidiasis, a decrease in creatinine clearance, increase in blood urea nitrogen (in patients with renal insufficiency), impairment of renal function; местные реакции — боль и инфильтрат в месте в/м введения; phlebitis, tromboflebit, pain along the vein (at / in the introduction).

Cooperation.

With simultaneous use of cephalosporins and nephrotoxic drugs with (incl. aminoglycosides, loop diuretics) increased nephrotoxicity. Tsefamandol incompatible with alcohol (inhibits atsetaldegiddegidrogenazu) and develop a joint application disulfiramopodobnyh reaction (abdominal pain, dermahemia, headache, nausea, vomiting, heartbeat, perifericheskaya vasodilation, accompanied by hypotension, increased perspiration). При одновременном применении с аминогликокозидами — синергизм антибактериального действия. Probenecid slows excretion and glomerular doubles C_max and duration. Tsefamandol interacts with oral anticoagulants and other drugs, influencing blood coagulation. Pharmaceutical incompatible with solutions of aminoglycoside.

Overdose.

Symptoms: convulsions (especially in patients with chronic renal failure).

Treatment: appointment of anticonvulsant drugs (diazepam or short-acting barbiturates), в тяжелых случаях — гемодиализ.

Dosing and Administration.

/ M, I /. Adults: по 0,5–1 г каждые 4–8 ч, при заболеваниях мочевыводящих путей — 0,5 g (в тяжелых случаях — 1 g) every 8 no, при угрожающих жизни инфекциях — до 2 g every 4 no (the maximum dose 12 g / day). Детям — 50–100 мг/кг/сут (with heavy infections is to 150 mg / kg) с интервалами между введениями 4–8 ч. When infections, caused by beta-hemolytic streptococcus, treatment should be continued for at least 10 days. If the kidney function mode set based on creatinine clearance. Пациентам на гемодиализе вводят по 1 g every 12 ч в/в или в/м (if you use the / m keeping, after completing hemodialysis additionally introduced 1 / 3-1 / 2 doses). Для профилактики послеоперационных инфекционных осложнений за 30–60 мин до вмешательства взрослым вводят 1–2 г, children - 50-100 mg / kg, с последующим применением тех же доз в течение 24–48 ч.

Precautions.

Be wary appoint newborns, premature babies, patients with severe renal impairment and with a history of colitis. Patients, with hypersensitivity to penicillins, possible cross-allergic reaction cephalosporin antibiotic. Care should be taken when appointing tsefamandola patients with a history of bleeding.

In exchange treatment is necessary to control the state of renal function (especially in patients, receiving high dose), determination of prothrombin time. Elderly and debilitated patients with renal dysfunction dose should be reduced in view of creatinine clearance. Prolonged treatment Tsefamandol may develop superinfection due to growth insensitive to the drug microflora. In the case of superinfection requires removal of the drug and the corresponding change in antibiotic therapy. После устранения симптомов заболевания лечение следует продолжать еще в течение 48–72 ч.

During treatment, possible false-positive direct Coombs' test, false positive reaction to urinary glucose and protein.

Cooperation