Amantadin

When ATH:
N04BB01

Characteristic.

Amantadine hydrochloride - white or white with a faint yellowish tinge crystalline powder. Soluble in water (1:20), alcohol, practically insoluble in ether.

Pharmacological action.
Antiparkinsonian, antiviral.

Application.

Parkinson's Disease, parkinsonizm (akinetic and rigid form); neuralgia in opoyasыvayushtem deprivation; loss of consciousness as a result of traumatic brain injury; slow recovery from anesthesia; prevention and treatment of influenza (Influenza A virus).

Contraindications.

Hypersensitivity, psychosis (incl. history), epilepsy, thyrotoxicosis, glaucoma, prostatic hyperplasia, liver and / or kidney failure, pregnancy (especially I trimester), breast-feeding.

Restrictions apply.

Congestive heart failure, hypotension, psychomotor agitation, confusion, hallucinations, liver and kidney disease, atopic dermatitis.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

From the nervous system and sensory organs: dizziness, insomnia, anxiety, irritability, reduced visual acuity, excitation, tremor, convulsions, heteroptics.

Cardio-vascular system and blood (hematopoiesis, hemostasis): development or exacerbation of congestive heart failure, tachycardia, orthostatic hypotension.

From the digestive tract: anorexia, nausea, dry mouth, dyspepsia.

Other: urinary retention in patients with benign prostatic hyperplasia, polyuria, nocturia, peripheral edema, dermatosis, the appearance of a bluish color of the skin of the upper and lower extremities.

Cooperation.

It enhances the effect of CNS stimulants. Compatible with the central and other anticholinergic antiparkinsonian.

Dosing and Administration.

Inside, after meal. Adults: the initial dose - 100 mg / day, if necessary through 1 weeks to increase doses up to 200 mg / day; The maximum daily dose - 400 mg. In connection with the possible aguirutm effect on the CENTRAL NERVOUS SYSTEM are advised to take the last dose no later than 16 no. If the kidney function in elderly patients and reduce the dose and increase the interval between doses. Typically, amantadine is prescribed in combination with other antiparkinsonian. B /: by 200 mg 1-3 times a day for 3 no (infusion rate of 50-60 drops / min).

For the prevention and treatment of influenza appoint 200 mg/day for a period of at least 10 days.

Precautions.

Avoid abrupt discontinuation of therapy. The treatment is contraindicated alcohol intake. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation