Trigeksifenidil

When ATH:
N04AA01

Characteristic.

White crystalline powder. It is soluble in water, slowly soluble in alcohol.

Pharmacological action.
Antiparkinsonian.

Application.

Parkinsonizm (idiopathic, atherosclerotic, postencephalitic, drug), Little's Disease, spastic paralysis, associated with damage to the pyramidal and extrapyramidal (less often) system.

Contraindications.

Hypersensitivity, zakrыtougolynaya glaucoma, urinary retention, benign prostatic hyperplasia (with the presence of residual urine), ileus, psychosis, dementia, pulmonary edema, pregnancy (I trimester).

Restrictions apply.

Auricular fibrillation, obstructive diseases of the digestive tract, decompensated heart disease, kidney, liver, arterial hypertension, advanced age.

Side effects.

From the nervous system and sensory organs: headache, dizziness, irritability, decreased ability to concentrate, delirium, hallucinations, fatigue, psychosis.

Effects, due to anticholinergic activity: dry mouth, Parez akkomodacii, increased intraocular pressure, constipation, urinary retention, tachycardia, violation of sweating.

From the digestive tract: nausea, vomiting.

Allergic reactions: skin rash.

Other: gnoynыy mumps (due to decreased salivation), dermahemia, muscle flaccidity, drug dependence.

Cooperation.

In a joint application with the histamine receptor blockers, phenothiazine derivatives, tricyclic antidepressants increase the expression of peripheral anticholinergic effects. Levodopa increases the activity of anti- (may reduce the dose), reserpine is reduces. Incompatible with alcohol.

Overdose.

Characterized by dysfunctions of the CENTRAL NERVOUS SYSTEM-agitation, delirium, hallucinations.

Dosing and Administration.

Inside, initial dose is 0.5-1 mg/day, the dose increases up to 5-10 mg for 1-3 reception.

Precautions.

Patients over 60 years prescribed with caution, tk. possible hypersensitivity to the drug (can significantly impair cognitive function and induce hallucinations, even in medium therapeutic doses). It is necessary to regularly monitor the intraocular pressure. Intensity of side effects during treatment decreases. Prolonged treatment may develop drug dependence.