CÏNKTERAL

Active material: Zinc Sulphate
When ATH: A12CB01
CCF: Preparation, filling shortage of zinc in the body
When CSF: 17.04.01
Manufacturer: Teva Kutno S.A. (Poland)

Pharmaceutical form, composition and packaging

◊ Pills, coated purple-pink, round.

	1 tab.
zinc sulphate monohydrate	124 mg,
that corresponds to the content of elemental zinc	45 mg

Excipients: pharmaceutical lactose, potato starch, polyvinylpyrrolidone, talc, magnesium stearate.

The composition of the shell: hydroxypropylmethylcellulose (Methocel E-5 premium), Titanium dioxide, polyoxyethylene (Carbowax 4000), Sicovit Azorubinlack (E122).

25 PC. – блистеры (1) – коробки картонные.
25 PC. – блистеры (2) – коробки картонные.
150 PC. – флаконы.

Pharmacological properties

Farmakodinamika.
Zinc is one of the most important trace elements, included in many enzyme systems, that regulate the basic metabolic processes, namely: participates in the synthesis of protein and carbohydrate. Zinc is necessary for the operation of more than 200 metalloenzymes (such as carbonic anhydrase, carboxypeptidase A, alcohol, Alkaline phosphatase, RNA polymerase, etc.), as well as to maintain the normal structure of nucleic acids, proteins and cell membranes. Zinc promotes the growth and development of cells, the proper functioning of the immune system and promote immunological response, twilight vision, taste sensations and perception of smell. Affects the maintenance of normal levels of vitamin a in the blood, lengthens duration of insulin and facilitates their accumulation. In inflammations of the skin has a prophylactic and therapeutic action.
Pharmacokinetics.

Regardless of the content of zinc in foods, in the duodenum and small intestine absorbed about 20-30% adopted zinc. The maximum concentration of zinc in plasma achieved through 2 h after dosing. Zinc in the body accumulates mainly in leukocytes and erythrocytes, as well as in muscle, bones, skin, kidney, liver, Pancreatic and prostate gland, retina. 60% Zinc is associated with albuminami, 30-40% with α₂-makrohlobulynom, 1% with amino acids, mainly with Histidine and cystine. Zinc excreted mainly with faeces (90%), to a lesser extent, in the urine and then.

Testimony

The treatment of zinc deficiency, caused by malnutrition, violation of the process of absorption of trace element, absorption or increased its loss by the body, observed when such conditions: alcoholism, burns, cirrhosis of the liver, diabetes, anorexia, Bulimia, status after gastrectomy, Genetic Diseases (Down's syndrome, enteropathic acrodermatitis, serpovidnokletochnaya anemia, Thalassemia), hemodialysis, chronic infections, cause a decrease in the reactivity of the immune system, intestinal parasitic infestations, pancreatic insufficiency, Cystic fibrosis of the pancreas, kidney disease (nephrotic syndrome, renal failure), bowel disease (celiac disease, Crohn's disease, celiac disease, yazvennыy colitis), short bowel syndrome, skin diseases (exfoliative dermatitis, psoriasis), prolonged stress, injury, diet.

APPLICATIONS

The agent shall inside adults and children over the age of 4 years. Usually take for 1 hours before or after 2 hours after meals, Since many foods interfere with the absorption of zinc. If you experience symptoms of irritation of the digestive tract, medication can be taken with food, but in this case it may decrease bioavailability.
Adult drug appoint 1-2 tablets per day. Children under the age of 4 years and adolescents appoint 1 tablet per day.
The duration of treatment is determined by physician individually, Depending on the extent of clinically proven zinc deficiency and therapeutic effect.

Contraindications

Hypersensitivity to the drug.

SIDE EFFECTS

In some cases there may be disorders of the digestive tract (nausea, dyspepsia, heartburn); haematological disorders, caused by copper deficiency, including leukopenia (fever, chills, sore throat), neutropenia (ulcers in the mouth and throat), sideroblastnaya anemia (a feeling of fatigue, weakness); headache and metallic taste in the mouth.

Cautions

When using drugs, containing zinc, must take into account the risk of copper deficiency. When the diet, rich fibrin (such as bran), fosfatami (dairy products such as), polnozernovymi bakery products and fitinatami, reduced absorption of zinc due to the formation of complexes. The break between the use of the above products and taking zinc preparations should not be less than 2 no.
Pregnancy and breast-feeding.
Zinc penetrates through the placental barrier and is excreted in breast milk. The drug is used during pregnancy only, if, According to the doctor, benefit to the mother outweighs the potential risk to the fetus. You must be wary appoint drug in breastfeeding.
Children. Drug use among children aged 4 years.
The ability to influence the reaction speed when driving or operating other machines.
Zinc salts do not affect the speed psychomotor reactions.

INTERACTION

Cinkteral reduces the absorption of tetracyclines and inhibits copper absorption (in the application of zinc at high doses), Therefore, it should be taken no earlier than 2 hours after taking these drugs.
Tiazidnye dioretiki increase zinc excretion in the urine.
Folic acid marginally violate intake of zinc.
Oral application of iron at high doses, penicillamine for and other chelating means reduced zinc absorption. The break between the use of these drugs and zinc salts should not be less than 2 no.
When applied simultaneously with Cinkteralom polyvitamins with minerals, containing zinc, must take into account the possibility of overdose.

Overdose

Can celebrate: burning in mouth and throat, watery or bloody diarrhea, painful urge to defecate, belching, hypotension (dizziness), jaundice, pulmonary edema (chest pain, difficulty breathing), vomiting, gematuriю, anuriyu, collapse, convulsions, gemoliz.
In the case of the above symptoms should drink milk or water, and then type in the/m or/in the dinatrievuju salt ethylenediaminetetraacetic acid at a dose of 50-75 mg/kg body weight per day for 3-6 no more introductions 5 days.

STORAGE CONDITIONS

At a temperature of 15-25° c.