TERAFLEKS

Active material: Chondroitin sulfate, Glucosamine
When ATH: M01BX
CCF: Preparation, regulates the metabolism of the cartilage
ICD-10 codes (testimony): M15, M42
When CSF: 16.05.01
Manufacturer: SAGMEL, Inc. (United States)

Pharmaceutical form, composition and packaging

◊ Capsules hard gelatin, size №0, clear; contents of capsules – white or white with a yellowish tinge crystalline and odorless powder inclusions, or with a weak specific smell.

Excipients: stearic acid, magnesium stearate, manganese sulfate.

Composition of a gelatin capsule: gelatin.

30 PC. – plastic bottles (1) – packs cardboard.
60 PC. – plastic bottles (1) – packs cardboard.
100 PC. – plastic bottles (1) – packs cardboard.

Pharmacological action

The stimulator of regeneration of cartilage.

Glucosamine hydrochloride and chondroitin sulfate are involved in the biosynthesis of connective tissue, helping to prevent the destruction of cartilage and processes by stimulating tissue regeneration. Exogenous glucosamine enhances the production of cartilage matrix and provides a non-specific protection against chemical damage to cartilage. Another possible effect of glucosamine is to protect the damaged cartilage from metabolic destruction, caused by NSAIDs and corticosteroids, and own a modest anti-inflammatory effect.

Chondroitin sulfate is an additional substrate for the formation of healthy cartilage matrix. It stimulates the production gialuronona, synthesis of proteoglycans and type II collagen, and protects it from enzymatic cleavage gialuronon (by inhibiting the activity of hyaluronidase); It maintains the viscosity of synovial fluid, It stimulates cartilage repair mechanisms and inhibits the activity of the enzymes (elastase, gialuronidaza), that break down cartilage. At treatment of osteoarthritis It alleviates the symptoms of the disease and reduces the need for NSAIDs.

Pharmacokinetics

Glucosamine sulfate

Absorption and distribution

The bioavailability of glucosamine ingestion of 25% (due to the effect “first pass” through the liver).

After absorption glucosamine radiolabeled initially detected in the plasma and later into the tissue. The highest concentrations are found in the liver, kidneys and articular cartilage. About 30% the dose persists in the long bone and muscle tissue.

Deduction

Write mainly with urine in unchanged form, partly with feces. T_1/2 – 68 no.

Chondroitin sulfate

Absorption

Bioavailability is about 12 %. When a single oral dose 800 mg (or 400 mg 2 times / day) plasma concentration is increased over 24 no.

Metabolism and excretion

It is metabolized by the desulfurization. Report the news. T_1/2 – 310 m.

Testimony

- Degenerative-dystrophic diseases of joints and spine: osteoarthritis of the I-III degree, osteochondrosis.

Dosage regimen

Adults and older children 15 years during the first three weeks of the drug is prescribed for 1 capsule 3 times / day; in the following days – by 1 capsule 2 times / day. Duration of treatment – 3-6 Months. If necessary, you can repeat courses of treatment, the duration of which is determined individually.

The drug is taken orally, regardless of the meal, with a little water.

Side effect

From the digestive system: epigastric pain, flatulence, diarrhea, constipation.

CNS: dizziness, headache, drowsiness, insomnia.

Other: tachycardia, peripheral edema, pain in the legs, allergic reactions.

Contraindications

- Severe renal insufficiency;

- Pregnancy;

- Lactation (breast-feeding);

- Up to 15 years;

- Hypersensitivity to the drug.

FROM caution should be prescribed for patients with diabetes, propensity to bleed, asthma.

Pregnancy and lactation

Clinical data on the efficacy and safety of the drug Teraflex^® Pregnancy and lactation are absent.

Cautions

When adverse reactions from the digestive system dose should be reduced to 2 times, in the absence of improvement – cancel product.

Terafleks^® It can be used as part of combination therapy with corticosteroids and NSAIDs.

Overdose

So far, cases of drug overdose Teraflex^® not disclosed. In case of overdose, the following symptoms: Hemorrhagic rash, nausea, vomiting.

Treatment: gastric lavage, simptomaticheskaya therapy.

Drug Interactions

It increases the absorption of tetracycline.

It reduces the effect of semi-synthetic penicillin and chloramphenicol.

Chondroitin sulfate enhances the effect of anticoagulants.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored in a dry, inaccessible to children at temperature not exceeding 25 ° C. Shelf life - 3 year.