Sulpyryd

When ATH:
N05AL01

Characteristic.

Atypical neuroleptic from the group of substituted benzamides. The racemic mixture of D- and L-isomers.

Pharmacological action.
Neuroleptic, antipsychotic, antiemetic.

Application.

Acute and chronic psychosis (incl. schizophrenia), depression, migraine, behavioral disorders in children, traumatic encephalopathy, dizziness various etiologies (incl. when vertebral-basilar insufficiency, vestibular neuritis, Meniere's disease, otitis media, recovering from traumatic brain injury), gastric ulcer and duodenal ulcer, GI ulcers (incl. stressful, and symptomatic medications).

Contraindications.

Hypersensitivity, pheochromocytoma, arterial hypertension, anxiety, affect, aggression and psychomotor agitation, Acute means, CNS depressants (alcohol, hypnotics, opioid analgesics, etc.), hyperprolactinemia.

Restrictions apply.

Age to 14 years, advanced age.

Pregnancy and breast-feeding.

Be wary of during pregnancy and breastfeeding, comparing the expected benefit to the mother and the potential risk to the fetus. With prolonged use of high doses (above 200 mg / day) sometimes observed in newborns extrapyramidal syndrome. If necessary, the treatment of pregnant and lactating women is recommended to reduce the dose and reduce the duration of treatment.

Side effects.

From the nervous system and sensory organs: headache, dizziness, sleep disorders, drowsiness, anxiety, irritability, excitation, pyramidal disorders, extrapyramidal syndrome, dyskinesia, akathisia, tremor, involuntary movements of the mouth, oral automatism, afazija, violation of visual acuity.

Cardio-vascular system and blood (hematopoiesis, hemostasis): orthostatic hypotension, increased blood pressure, tachycardia.

From the digestive tract: dry mouth, heartburn, nausea, vomiting, constipation, increase in liver transaminases and alkaline phosphatase.

With the genitourinary system: galactorrhea, gynecomastia, menstrual irregularities, frigidity, impotence.

Allergic reactions: skin rash, itch.

Other: neuroleptic malignant syndrome (incl. hyperthermia), weight gain, Sweating, exacerbation of eczema.

Cooperation.

It enhances the effect of morphine derivatives, ʙarʙituratov, benzodiazepines, clonidine and alcohol. Simultaneous treatment with antihypertensive drugs increases the risk of orthostatic hypotension. Incompatible with levodopa (antagonizm).

Overdose.

Symptoms: blurred vision, arterial hypertension, arrhythmia, pronounced sedation, dry mouth, nausea, vomiting, extrapyramidal symptoms, desudation.

Treatment: gastric lavage, administration of activated charcoal, simptomaticheskaya therapy. No specific antidote.

Dosing and Administration.

Inside, in/m. Inside, in the first half of the day (not later 16 no) 2-3 hours. Dose selected individually, depending on the evidence, Portability, clinical disease. A single dose of 50-100 mg, average - 100-600 mg / day, highest daily - 1200 mg. Elderly patients with renal failure and initiate treatment with lower dose with gradual increase in the need. Children over 14 years: 3–5 мг/кг/сут (if necessary - up 10 mg / kg / day).

Precautions.

Be wary appoint patients with diseases of the cardiovascular system, renal failure, epilepsy, parkinsonizmom, Young women with irregular menstrual cycles.

With the development of hyperthermia (manifestation of neuroleptic malignant syndrome) sulpiride should be abolished.

During treatment should refrain from driving and other activities, require attention and speed of mental and motor responses, Avoid drinking alcohol.

Cooperation