Nervous: instructions for using the medicine, structure, Contraindications

Active material: Flurbyprofen
When ATH: M01AE09
CCF: NSAIDs
ICD-10 codes (testimony): J00, J02, J03, K05, K12, R07
When CSF: 05.01.03.02
Manufacturer: RECKITT BENCKISER HEALTHCARE INTERNATIONAL Ltd. (Great Britain)

Nervous: dosage form, composition and packaging

◊ Lozenges (Medovo--limonnыe) round, of translucent caramel mass, from light yellow to light brown color, с изображением буквы “S” с двух сторон таблетки; It allowed the presence of air bubbles in the mass of caramel and slight rough edges; may appear white bloom.

Excipients: macrogol 300, Sodium hydroxide, lemon flavor 502904A, levomenthol, honey, liquid sucrose, dextrose.

8 PC. – блистеры (1) – пачки картонные.
8 PC. – блистеры (2) – пачки картонные.
8 PC. – блистеры (3) – пачки картонные.

Nervous: pharmachologic effect

NSAIDs. The mechanism of action of flurbiprofen is associated with inhibition of the enzyme COX-1 and COX-2, followed by prostaglandin synthesis inhibition - mediators of pain. Anti-inflammatory and analgesic effect.

The therapeutic effect of the drug develops within 30 min after the start of resorption tablet in the oral cavity and extends for 2-3 no.

Nervous: pharmacokinetics

Absorption and distribution

Rapidly absorbed from the gastrointestinal tract. C_max plasma levels achieved after 30-40 m.

Plasma protein binding - more 99%.

Metabolism and excretion

Biotransformed in the liver by hydroxylation.

Excreted in the urine. T_1/2 is 3-6 no.

Nervous: testimony

• infectious and inflammatory diseases of the oral cavity and pharynx (as agents for the symptomatic relief of pain).

Nervous: dosing regimen

Adults and children over 12 years It is recommended to take 1 tab. as needed.

Do not use more than 5 tab. during 24 no.

Do not take the drug more 3 days.

Tablets dispersible oral until complete dissolution. When resorption should move across the tablet oral, in order to avoid damage to the mucosa at the site of absorption.

Nervous: side effects

Local reactions: distortion of taste, paresthesia (burning, pricking, tingle), ulceration of the mucous membranes of the mouth.

Before the drug orally at a dose 50-100 mg 2-3 times / day (12-30 tab. / day) can be observed:

From the digestive system: dyspepsia (nausea, vomiting, heartburn, diarrhea), gastropathy, abdominal pain, abnormal liver function; long-term use at high doses - ulceration of the gastrointestinal mucosa, bleeding (incl. gums and hemorrhoids).

Cardio-vascular system: increased blood pressure, tachycardia, heart failure.

From the hematopoietic system: rarely - anemia (iron, hemolytic, aplastic), agranulocytosis, leukopenia, thrombocytopenia.

From the central and peripheral nervous system: headache, dizziness, drowsiness or insomnia, asthenia, depression, amnesia, tremor, excitation; are rarely - ataxia, paresthesia, disturbance of consciousness.

From the urinary system: tubulointerstitial nephritis, edematous syndrome, impairment of renal function.

Allergic reactions: skin rash, itch, hives, bronchospasm, photosensitivity, angioedema, anaphylactic shock.

Other: hearing loss, noise in ears, increased sweating.

Nervous: Contraindications

• stomach ulcer (exacerbation);
• bronchial asthma and rhinitis while taking acetylsalicylic acid or other NSAIDs;
• deficiency of glucose-6-fosfatdegidrogenazы;
• Children up to age 12 years;
• pregnancy;
• lactation (breast-feeding);
• hypersensitivity to the drug.

FROM caution use in patients with hyperbilirubinemia (incl. Gilbert's syndrome, Dubin-Johnson and Rotor), chronic heart failure, edema, hypertension, gemofilii, reducing blood clotting, gastric ulcer or duodenal ulcer (in remission, history), kidney and / or liver failure, suppression of bone marrow hematopoiesis, hearing loss, pathology of the vestibular apparatus, as well as in elderly patients.

Nervous: Pregnancy and lactation

Application Strepfen^® contraindicated during pregnancy. If necessary, the appointment during lactation should decide the issue of termination of breastfeeding.

Nervous: Special instructions

In the case of a combination of pain in the throat with a significant increase in body temperature the drug can be recommended by a doctor.

If you want to determine the 17-ketosteroids drug should be discontinued for 48 h before the test.

Diabetics should take into account, the tablet contains about 2.5 g sugar.

Patients should be warned, that if the high temperature, occurrence of headaches or other adverse events should consult a doctor.

Nervous: overdose

Symptoms: when receiving 1 g - sleepiness; more 1.5 g - excitement; 2.5-4 g - nausea, headache, dizziness, epigastric pain, diplopia, mioz, gipotonus; more 4 g - depression of consciousness up to coma.

Treatment: the drug should be discontinued; if necessary, symptomatic therapy.

Nervous: drug interaction

In a joint application with the drug Strepfen^® Inductors of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites of flurbiprofen.

In an application Strepfen^® reduces the effectiveness of drugs urikozuricheskih; enhances the effect of anticoagulants (the risk of bleeding), antiagregantov, fibrinolitikov, side effects of mineralogy- and glucocorticoids, estrogen.

In an application Strepfen^® reduces the efficacy of antihypertensive and diuretic.

In an application Strepfen^® enhances hypoglycemic effect of sulfonylurea derivatives.

In an application Strepfen^® It increases the blood concentration of drugs lithium, methotrexate.

Nervous: terms of dispensing from pharmacies

The drug is approved for use as a means of tempering beretsepturnogo.

Nervous: terms and conditions of storage

The drug should be stored in a dry, protected from moisture, inaccessible to children at temperature to 25 ° C. Shelf life - 3 year.