Sparfloxacine

When ATH:
J01MA09

Characteristic.

Sun of fluoroquinolones Group III generation.

Pharmacological action.
Antibacterial, bactericide.

Application.

Respiratory infections ways and otolaryngology (incl. pneumonia, exacerbation of chronic obstructive pulmonary disease, otitis, sinusitis); disease, Sexually Transmitted Infections (gonorrhea, Chlamydia); GI infections, caused by Shigella and salmonella; infections of the urinary tract (uretrit, cystitis, pyelitis); infections of skin and soft tissue (infected wounds, abscess, pyoderma, furunculosis, infective Dermatitis); surgical infection.

Contraindications.

Hypersensitivity (incl. to other quinolones), a history of photosensitivity reactions, insufficiency glukozo − 6-phosphate-dehydrogenase deficiency, QT prolongation, simultaneous IA complications funds or III classes and antigistaminnah preparations (terfenadine, astemizol), pregnancy, lactation, Age to 18 years (Safety and efficacy have not been determined; it should be understood, that sparfloxacin is cause arthropathy in young growing animals).

Restrictions apply.

Cerebral atherosclerosis, epilepsy, renal failure.

Pregnancy and breast-feeding.

Category actions result in FDA - C. (The study of reproduction in animals has revealed adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not held, However, the potential benefits, associated with drugs in pregnant, may justify its use, in spite of the possible risk.)

Side effects.

From the nervous system and sensory organs: dizziness, drowsiness, headache, nervousness, insomnia, CNS stimulation (acute psychosis, ažitaciâ, confusion, hallucinations, tremor).

Cardio-vascular system and blood (hematopoiesis, hemostasis): QT prolongation, vasorelaxation, leukocytosis.

From the digestive tract: nausea, vomiting, diarrhea, change in taste, pain or discomfort in the abdomen, psevdomembranoznыy colitis (pronounced abdominal or stomach cramps and pain, severe diarrhea, incl. with blood, fever).

With parties of the musculoskeletal system: arthralgia, myalgia, Tendinitis, arthropathy, tendon rupture.

For the skin: photosensitivity reaction (Blisters, itch, rash, hyperemia, burning sensation skin, puffiness).

Allergic reactions: skin rash, itch, redness.

Other: vaginal candidiasis, increase in serum transaminases (GOLD, IS, alkaline phosphatase).

Cooperation.

Sparfloxacin does not alter farmakokinetiku zimetidina, digoksina, probenecid, or other methylxanthines theophylline, varfarina.

PM, prolongiruûŝie QT interval (IA antiarrhythmics or class III, incl. Amiodarone, cisapride, disopyramide, tricyclic antidepressants, fenotiazinы, terfenadine, astemizol, Erythromycin, pentamidine), increase the risk of fracture QT interval and torsade de pointes development (Avoid simultaneous use).

Antacids (aluminum-containing, magnesium, calcium), sucralfate; PM, containing metal cations, incl. iron, zinc, may reduce the absorption of sparfloksacina and its concentration in the blood (concurrent use is not recommended).

Overdose.

Treatment: gastric lavage, simptomaticheskaya therapy, ECG monitoring. No specific antidote.

Dosing and Administration.

Inside (regardless of the meal). The first admission- 400 mg in the morning, in the coming days — on 200 mg once daily. The duration of treatment depends on the severity of the disease, clinical course and the results of bacteriological examination and is usually 10 days. In patients with moderate and severe disabilities kidney required dose adjustment, the elderly and against the background of human liver dose adjustment is not required. In renal insufficiency (creatinine clearance less than 50 ml / min) appointed 400 mg on the first day, then 200 mg once every two days, duration of the course is usually 9 days.

Precautions.

It will be appreciated, that treatment with sparfloksacinom possible extension QT interval, Therefore there is a need for caution when it is assigned to patients with disorders of the cardiovascular system in the presence of factors, contributing to the development of arrhythmias (eg, When expressed bradikardii, Congestive heart failure, atrial fibrillation, the presence of hypokalemia, etc.). In view of the opportunities for development need to be applied to reactions of caution in diseases, predisposing to seizures.

During treatment and for 5 days after the end of therapy should be avoided UV irradiation.

Cautions.

In connection with the available reports of tendon rupture, incl. Shoulder, hands and Achilles tendon, observed when taking fluoroquinolones, should discontinue treatment with the appearance of specific complaints (pain, inflammation, tendon rupture).

Sparfloxacin should be taken for 1-2 hours before or at least 4 h after administration antatsidov.

Cooperation