SORBILAKT

Active material: combined preparation
When ATH: B05XA31
CCF: Plasma-drug
ICD-10 codes (testimony): A40, A41, E05, E86, G93.6, K65.0, K72, K73, K81.0, K81.1, K91.3, N17, R57.1, R57.8, T79.4
When CSF: 21.05.01
Manufacturer: YURI-FARM Ltd. (Ukraine)

dosage form, composition and packaging

Solution for infusion clear, colorless.

Excipients: water d / and.

200 ml – glass bottles (1) – packs cardboard.
400 ml – glass bottles (1) – packs cardboard.

Pharmacological action

Plasma-drug. It has protivoshokovoe, Energy, detoxification, alkalizing, diuretic and stimulates peristalsis action.

The main pharmacologically active substances are sorbitol (in a hypertonic concentration) and sodium lactate (in an isotonic concentration). In the liver sorbitol first converted to fructose, which is then converted to glucose, and then to glycogen. Part of sorbitol used for urgent energy needs, the other part is deposited as a reserve in the form of glycogen. The hypertonic solution of sorbitol has a large osmotic pressure and expressed ability to increase urine output.

Unlike sodium bicarbonate, correction of metabolic acidosis with sodium lactate is slower, as its inclusion in the metabolism, without causing sharp fluctuations in pH. The action of sodium lactate is manifested through 20-30 minutes after administration.

Sodium chloride – plazmozameshchath means, manifests detoxification, rehydration action, It eliminates the deficiency of sodium and chlorine in various pathological conditions.

Calcium chloride eliminates deficiency of calcium ions. Calcium ions are required for the process of transmission of nerve impulses, contraction of skeletal and smooth muscle, Activities infarction, bone formation, clotting. It reduces the permeability of cells and the vascular wall, It prevents the development of inflammatory reactions, increases resistance to infection, and can greatly enhance phagocytosis.

Potassium chloride restores water and electrolyte balance. It shows a negative chrono- and bathmotropic action, high dose – negative for-, dromotropic and mild diuretic effect. It participates in the process of nerve impulses. It increases the content of acetylcholine and causes excitation of the sympathetic division of the autonomic nervous system. It improves the process of reduction of skeletal muscle in muscular dystrophy, myasthenia.

Pharmacokinetics

Sorbitol quickly included in the overall metabolism, 80-90% which is utilized in the liver and stored as glycogen. 5% is deposited in the brain tissue, heart muscle and skeletal muscle. 6-12% excreted in the urine.

When introduced into the bloodstream of sodium lactate is reacted with carbon dioxide and water, forming sodium bicarbonate, which leads to an increase in alkaline reserve of blood. Active considered only half entered sodium lactate (L isomer), and the other half (Isomer D) It is not metabolized and excreted in the urine.

Sodium chloride is rapidly cleared from the vascular, temporarily increasing bcc. Increases diuresis.

Testimony

To reduce the toxicity, improve microcirculation, Correction of acid-base balance, improve hemodynamics:

- Traumatic, operating, hemolytic and burn shock;

- Peritonitis and intestinal obstruction (in front of- and postoperative period);

- Acute renal insufficiency of various etiologies;

- Thyrotoxicosis;

- Sepsis;

- Various liver diseases (gepatitah, cholecystitis, acute and subacute liver disease, hepatic coma);

- Increased intracranial pressure in the case of cerebral edema.

Dosage regimen

Sorʙilakt^® introduced adult in / bolus or infusion (60-80 drops / min).

At traumatic, Burn, postoperative and hemolytic shock – by 200-400 ml 600 ml (3-10 ml / kg body weight), single, first jet, then – drop.

At liver diseases – dose 200 ml (3.5 ml / kg body weight) drip once and again, daily or every other day.

At Acute renal failure – single dose 200-400 ml (to 2.5-6.5 ml / kg body weight) drip or stream (cherez again 8-12 no).

To prevention of postoperative intestinal paresis – 150-300 ml (2.5-5 ml / kg body weight) for single injection, drop; may be repeated after every infusion 12 h during the first 2-3 day after surgery.

To treatment of postoperative paresis – dose 200-400 ml (3.5-6.5 ml / kg body weight) drop, every 8 h to the normalization of intestinal motility.

At swelling of the brain – first jet, and then drip (60-80 drops / min) dose 5-10 ml / kg body weight.

At significant dehydration / v infusion Sorbilakta^® It should be done only drip (no more 200 ml / day).

Children under 6 years administration to the recommended dose rate 10 ml / kg body weight, aged 6 to 12 years – dose, is half the dose for adult, older children 12 years the dose is the same, as for adults.

Side effect

There are: alkalosis and dehydration (due to hyperosmolar solutions), allergic reactions (skin rash, itch).

Contraindications

- Alkalosis;

- In cases, when contraindicated infusion of large volumes of fluid (cerebral hemorrhage, thromboembolism, circulatory decompensation, Article III hypertension.);

- Hypersensitivity to the drug.

FROM caution It should be prescribed to patients with impaired liver function, ulcer, hemorrhagic colitis.

Pregnancy and lactation

Data on the use of the drug Sorbilakt^® Pregnancy and lactation are absent.

Cautions

The drug is used under the control of parameters of acid-base balance and blood electrolytes, as well as liver function.

To use caution in patients with calculous cholecystitis.

The drug is used, given osmolarity of blood and urine, and acid-base status.

Introduction Sorbilakta^® patients with diabetes should be under the control of blood glucose.

Overdose

Simtpomy: phenomenon occurs alkalosis, that quickly pass on their own, subject to an immediate cessation of drug administration.

Treatment: the dehydration symptomatic therapy.

Drug Interactions

Sorʙilakt^® should not be mixed with phosphate- and a carbonate-containing solution.

Not used as a carrier solution for other drugs.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, protected from light, reach of children, at a temperature of from 2 ° to 25 ° C.. Shelf life – 2 year.