Active material: combined preparation
When ATH: B05XA31
CCF: Plasma-drug
ICD-10 codes (testimony): A40, A41, E05, E86, G93.6, K65.0, K72, K73, K81.0, K81.1, K91.3, N17, R57.1, R57.8, T79.4
When CSF: 21.05.01
Manufacturer: YURI-FARM Ltd. (Ukraine)
dosage form, composition and packaging
Solution for infusion clear, colorless.
| 1 l | |
| sorbitol | 200 g |
| Sodium lactate | 19 g |
| sodium chloride based on dry solids | 6 g |
| calcium chloride | 100 mg |
| potassium chloride | 300 mg |
| magnesium chloride, based on dry substance | 200 mg, |
| incl. | |
| On+ | 278.16 mmol |
| K+ | 4.02 mmol |
| Ca2+ | 0.9 mmol |
| Mg2+ | 2.1 mmol |
| Cl– | 112.69 mmol |
| CH3CH(OH)COO– | 175.52 mmol |
| Theoretical osmolarity 1670 mOsm / l | |
Excipients: water d / and.
200 мл – флаконы стеклянные (1) – пачки картонные.
400 мл – флаконы стеклянные (1) – пачки картонные.
Plasma-drug. It has protivoshokovoe, Energy, detoxification, alkalizing, diuretic and stimulates peristalsis action.
The main pharmacologically active substances are sorbitol (in a hypertonic concentration) and sodium lactate (in an isotonic concentration). In the liver sorbitol first converted to fructose, which is then converted to glucose, and then to glycogen. Part of sorbitol used for urgent energy needs, the other part is deposited as a reserve in the form of glycogen. The hypertonic solution of sorbitol has a large osmotic pressure and expressed ability to increase urine output.
Unlike sodium bicarbonate, correction of metabolic acidosis with sodium lactate is slower, as its inclusion in the metabolism, without causing sharp fluctuations in pH. The action of sodium lactate is manifested through 20-30 minutes after administration.
Натрия хлорид – плазмозамещающее средство, manifests detoxification, rehydration action, It eliminates the deficiency of sodium and chlorine in various pathological conditions.
Calcium chloride eliminates deficiency of calcium ions. Calcium ions are required for the process of transmission of nerve impulses, contraction of skeletal and smooth muscle, Activities infarction, bone formation, clotting. It reduces the permeability of cells and the vascular wall, It prevents the development of inflammatory reactions, increases resistance to infection, and can greatly enhance phagocytosis.
Potassium chloride restores water and electrolyte balance. It shows a negative chrono- and bathmotropic action, в высоких дозах – отрицательное ино-, dromotropic and mild diuretic effect. It participates in the process of nerve impulses. It increases the content of acetylcholine and causes excitation of the sympathetic division of the autonomic nervous system. It improves the process of reduction of skeletal muscle in muscular dystrophy, myasthenia.
Sorbitol quickly included in the overall metabolism, 80-90% which is utilized in the liver and stored as glycogen. 5% is deposited in the brain tissue, heart muscle and skeletal muscle. 6-12% excreted in the urine.
When introduced into the bloodstream of sodium lactate is reacted with carbon dioxide and water, forming sodium bicarbonate, which leads to an increase in alkaline reserve of blood. Active considered only half entered sodium lactate (L isomer), and the other half (Isomer D) It is not metabolized and excreted in the urine.
Sodium chloride is rapidly cleared from the vascular, temporarily increasing bcc. Increases diuresis.
To reduce the toxicity, improve microcirculation, Correction of acid-base balance, improve hemodynamics:
- Traumatic, operating, hemolytic and burn shock;
- Peritonitis and intestinal obstruction (in front of- and postoperative period);
- Acute renal insufficiency of various etiologies;
- Thyrotoxicosis;
- Sepsis;
- Various liver diseases (gepatitah, cholecystitis, acute and subacute liver disease, hepatic coma);
- Increased intracranial pressure in the case of cerebral edema.
Sorʙilakt® introduced adult in / bolus or infusion (60-80 drops / min).
At traumatic, Burn, postoperative and hemolytic shock - By 200-400 ml 600 ml (3-10 ml / kg body weight), single, first jet, затем – капельно.
At liver diseases – в дозе 200 ml (3.5 ml / kg body weight) drip once and again, daily or every other day.
At Acute renal failure – в разовой дозе 200-400 ml (to 2.5-6.5 ml / kg body weight) drip or stream (cherez again 8-12 no).
To prevention of postoperative intestinal paresis – 150-300 ml (2.5-5 ml / kg body weight) for single injection, drop; may be repeated after every infusion 12 h during the first 2-3 day after surgery.
To treatment of postoperative paresis – в дозе 200-400 ml (3.5-6.5 ml / kg body weight) drop, every 8 h to the normalization of intestinal motility.
At swelling of the brain – сначала струйно, and then drip (60-80 drops / min) dose 5-10 ml / kg body weight.
At significant dehydration / v infusion Sorbilakta® It should be done only drip (no more 200 ml / day).
Children under 6 years administration to the recommended dose rate 10 ml / kg body weight, aged 6 to 12 years – в дозе, is half the dose for adult, older children 12 years the dose is the same, as for adults.
There are: alkalosis and dehydration (due to hyperosmolar solutions), allergic reactions (skin rash, itch).
- Alkalosis;
- In cases, when contraindicated infusion of large volumes of fluid (cerebral hemorrhage, thromboembolism, circulatory decompensation, Article III hypertension.);
- Hypersensitivity to the drug.
FROM caution It should be prescribed to patients with impaired liver function, ulcer, hemorrhagic colitis.
Data on the use of the drug Sorbilakt® Pregnancy and lactation are absent.
The drug is used under the control of parameters of acid-base balance and blood electrolytes, as well as liver function.
To use caution in patients with calculous cholecystitis.
The drug is used, given osmolarity of blood and urine, and acid-base status.
Introduction Sorbilakta® patients with diabetes should be under the control of blood glucose.
Simtpomy: phenomenon occurs alkalosis, that quickly pass on their own, subject to an immediate cessation of drug administration.
Treatment: the dehydration symptomatic therapy.
Sorʙilakt® should not be mixed with phosphate- and a carbonate-containing solution.
Not used as a carrier solution for other drugs.
The drug is released under the prescription.
List B. The drug should be stored in a dry, protected from light, reach of children, at a temperature of from 2 ° to 25 ° C.. Shelf life - 2 year.
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