Solpadein: instructions for using the medicine, structure, Contraindications

Active material: Caffeine, Codeine, Paracetamol
When ATH: N02BE51
CCF: Analgesics, antipyretics combined structure
ICD-10 codes (testimony): G43, J06.9, J10, K08.8, M25.5, M54.1, M79.1, M79.2, N94.4, N94.5, R07, R50, R51, R52.0, R52.2, T14.3
When CSF: 03.02.01.03
Manufacturer: GlaxoSmithKline Consumer Healthcare (Great Britain)

Solpadein: dosage form, composition and packaging

◊ Soluble tablets white, flat, chamfered, smooth on one side and scored – with another.

Excipients: sodium bicarbonate, sorbitol, sodium saccharin, sodium lauryl, Citric acid anhydrous, anhydrous sodium carbonate,, polyvidone, Dimethicone.

2 PC. – strips (2) – cardboard boxes.
2 PC. – strips (4) – cardboard boxes.
2 PC. – strips (6) – cardboard boxes.
2 PC. – strips (12) – cardboard boxes.
2 PC. – strips (30) – cardboard boxes.

Solpadein: pharmachologic effect

Analgesics, antipyretics combined structure, contains a combination of three active ingredients.

Paracetamol okazыvaet zharoponizhayushtee and analygeziruyushtee action.

Caffeine has a general tonic effect (reduces drowsiness and fatigue, enhances mental and physical performance, increases HEART RATE, increases ad with hypotonia), enhances the analgesic effects of the drug.

Codeine has an analgesic effect and improves pain tolerance.

Solpadein: pharmacokinetics

The farmakokinetike drug Lamisil is not provided.

Solpadein: testimony

Pain syndrome in adults and children over the age 12 years, including:

• headache;
• toothache;
• migraine;
• pain in muscles and joints;
• neuralgia;
• painful menstruation;
• in radicles;
• with sprains;
• in sinusitis;
• sore throat.

To reduce the elevated body temperature in adults and children older than 12 years when cold, other infectious and inflammatory diseases and flu.

Solpadein: dosing regimen

Adults appoint 2 tab. 3-4 times / day at intervals of at least 4 no. The maximum single dose is 2 tab., the maximum daily dose – 8 tab.

Children aged 12 to 16 years appoint 1 tab. 3-4 times / day at intervals of at least 4 no. The maximum single dose 1 tab., the maximum daily dose – 4 tab.

Tablets before taking should dissolve in half glass of water.

The drug should not be taken more than 5 days in the appointment as an analgesic and more 3 days as antipyretic. Changing the dose and the interval between meals installs doctor.

Solpadein: side effects

From the digestive system: nausea, epigastric pain; rarely – constipation.

Allergic reactions: skin rash, itch, hives, angioedema.

From the hematopoietic system: rarely – anemia, thrombocytopenia, metgemoglobinemiâ.

CNS: rarely – sleep disturbance, drowsiness, dizziness.

Other: cardiopalmus.

At long-term use in doses, greatly exceeding the recommended, It increases the likelihood of the liver and kidneys.

Solpadein: Contraindications

• severe impairment of liver or kidney function;
• blood disease (thrombocytopenia, anemia);
• genetic absence of glucose-6-phosphate dehydrogenase;
• glaucoma;
• respiratory insufficiency, State after craniocerebral injury, increased intracranial pressure;
• arterial hypertension;
• concomitant use of other paracetamol-containing drugs;
• pregnancy;
• breastfeeding;
• childhood (to 12 years);
• increased individual sensitivity to paracetamol, codeine, caffeine or any ingredient of the drug.

FROM caution the drug should be used with Gilbert syndrome (constitutional giperbilirubinemia), congenital hyperbilirubinemia (Dubin-Johnson and Rotor), asthma, as well as in old age.

Solpadein: Special instructions

The caution should appoint Solpadeine in bronchial asthma or other respiratory disease, while receiving antidepressants, antiemetics, as well as lipid lowering drugs.

While taking the drug is not recommended for excessive consumption of tea and coffee, as this may lead to the initiation of, disruption of sleep, tachycardia, cardiac arrhythmias.

With prolonged use at dosages, greatly exceeding the recommended, necessary to monitor patterns of peripheral blood.

In order to avoid toxic to liver patients, host Solpadeine, should refrain from drinking alcohol. Not recommended to prescribe the drug for alcoholism.

Because the product is codeine, It should be borne in mind the possibility of the development of addiction.

Effects on ability to drive vehicles and management mechanisms

Solpadeine may cause drowsiness. In this case, admission Solpadeina should refrain from driving motor vehicles and activities potentially hazardous activities, require high concentration and speed of psychomotor reactions.

Solpadein: overdose

In case of overdose you should immediately seek medical assistance, even if the well-being.

Symptoms: nausea, vomiting, stomachache, Sweating, pale skin, tachycardia; in mild intoxication – tinnitus; with severe intoxication – confusion, drowsiness, collapse, convulsions, bronchospasm, labored breathing.

Treatment: gastric lavage, appoint adsorbents (Activated carbon), symptomatic therapy.

Solpadein: drug interaction

When taken for a long time Solpadeine proximity effect anticoagulants (warfarin and other coumarin), that increases the risk of bleeding.

Inductors of microsomal oxidation in the liver (phenytoin, difenin, ethanol, barbiturates, Carbamazepine, flumetsinol, rifampicin, zidovudine, phenylbutazone and tricyclic antidepressants) increase the production of hydroxylated active metabolites, Hence the possibility of severe intoxication with a slight excess of dosage.

Inhibitors of microsomal oxidation (incl. cimetidine) reduce the risk of hepatotoxicity of paracetamol.

Metoclopramide and domperidone increase, and cholestyramine reduces the absorption rate of paracetamol.

Solpadeine together reduces the effectiveness of urikozuričeskih drugs.

Caffeine speeds up absorption of ergotamine.

Codeine aggravating pills, analgesics and sedatives.

Ethanol increases T_1/2 Paracetamol, increasing the risk of hepatotoxic action.

Solpadein: terms of dispensing from pharmacies

The drug is resolved to application as an agent Valium holidays.

Solpadein: terms and conditions of storage

The drug should be stored out of reach of children at or above 25 ° C. Shelf life – 4 year.