Active material: Azelaic acid
When ATH: D10AX03
CCF: Drug for the treatment of acne and rosacea
ICD-10 codes (testimony): L70, L71.9, L81
When CSF: 29.12.01
Manufacturer: INTENDIS GmbH (Germany)
◊ Cream 20% white, opaque, mat.
| 1 g | |
| azelaic acid | 200 mg |
Excipients: benzoic acid, arlaton 983 S, quince, cetiriloktanoat, propylene glycol, glycerol 85%, Purified water.
30 г – тубы алюминиевые (1) – пачки картонные.
◊ Gel for external use 15% white to yellowish-white, opaque.
| 1 g | |
| azelaic acid micronized | 150 mg |
Excipients: lecithin, trigliceridy, polysorbate 80, propylene glycol, polyacrylic acid, Sodium hydroxide, disodium эdetat, benzoic acid, Purified water.
5 г – тубы алюминиевые (1) – пачки картонные.
30 г – тубы алюминиевые (1) – пачки картонные.
50 г – тубы алюминиевые (1) – пачки картонные.
The drug for the treatment of acne vulgaris, or common, and hyperpigmentation. Normalizes the process of keratinization in the wall of the follicles of the sebaceous glands, reducing the content of free fatty acids in the lipids of the skin. Exhibit antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis. Azelaic acid dose-dependently inhibited the growth and vitality of abnormal melanocytes.
Absorption
After application to the skin cream Skinoren azelaic acid is practically not absorbed into the systemic circulation (about 3.6% when applied 5 g of gel or cream).
Deduction
Some suck azelaic acid excreted by the kidneys in unchanged form, and a part of the dicarboxylic acid (C5, C7), formed of azelaic acid by beta-oxidation.
- Acne (acne vulgaris);
- Giperpigmentatsiya, incl. melasma, chloasma (Cream);
- Rosacea (Gel).
The dosage regimen and duration of therapy is determined individually. The drug is used without age restrictions.
Before using the product the skin should be cleaned with water or a mild detergent cosmetic product, then dry.
Cream or gel is applied to the affected skin evenly with a thin layer 2 times / day (in the morning and in the evening) and lightly rubbed. The drug should be used in sufficient quantities, but not excessively (about 2.5 enough to see the entire surface of the face). The drug should be used regularly throughout the course of treatment, the duration of which depends on the clinical disease and the severity of the symptoms). At acne (acne vulgaris) improvement usually occurs within 4 of the week. For best results, use of the drug should continue for several months.
At Melasma the drug is used in the form of a cream. The minimum duration of therapy is 3 Months, For best results, you should regularly use the cream Skinoren. During the entire period of treatment of melasma, be sure to apply in parallel with skinorenom wide range of sunscreens (UVB and UVA), to prevent exposure to the sun caused by the aggravation of the disease and / or re-pigmentation of the bleached areas.
Local reactions: rarely (preferably at the beginning of therapy) – местнораздражающее действие, hyperemia, peeling, эritema, burning sensation, itch, that, usually, not pronounced and are alone in the further course of treatment.
In very rare cases, allergic skin reactions (rash); при применении геля – контактный дерматит, folliculitis.
- Hypersensitivity to the drug.
Given the low systemic bioavailability and low toxicity of azelaic acid can be applied during lactation (breast-feeding), tk. the amount of azelaic acid, which can get the baby with breast milk, insignificant and does not involve any danger.
IN experimental studies in laboratory animals have not revealed the possible risk of the drug during pregnancy.
Avoid contact with the eyes, and the mucous membranes of the nose, lips and mouth; при случайном контакте – немедленно промыть водой.
In case of severe skin irritation expressed in the first weeks of treatment may be used Skinoren 1 time / day; if necessary, can be short-term removal of the drug (for a few days). After the disappearance of the symptoms of skin irritation should resume regular use of the drug at the recommended dose.
Epidermal and dermal-epidermal mixed types of melasma respond well to therapy cream Skinoren. When dermal melasma cream Skinoren is not effective. For the differential diagnosis is recommended to use the lamp Wood.
Animal studies showed no risk of acute intoxication in single overdose (when applied topically) or accidental ingestion.
Skinoren drug interactions with other drugs has not yet been identified.
The drug is resolved to application as an agent Valium holidays.
The drug in the form of a cream should be stored at a temperature no higher than 30 ° C. Shelf life - 5 years.
The drug is in the form of gel should be stored at a temperature no higher than 25 ° C. Shelf life - 3 year.
This site uses cookies and services to collect technical data from visitors to ensure performance and improve the quality of service.. By continuing to use our site, you automatically agree to the use of these technologies.
Read More