Pyolysin

Active material: culture medium filtrate broth cultures of microorganisms, Salicylic acid, Zinc oxide
When ATH: D11AX
CCF: The preparation with antimicrobial, anti-inflammatory, immunostimulant and improves tissue regeneration action
ICD-10 codes (testimony): H00, H60, I83.2, I84, L01, L02, L03, L03.3, L08.0, L30.3, L70, L73.2, L89, N61, T30, T79.3
When CSF: 29.01.15.01
Manufacturer: Serumwerk Bernburg AG (Germany)

Pharmaceutical form, composition and packaging

◊ Ointment for external application white or nearly white, Homogeneous, with shiny surface, with a weak characteristic odor with no signs of rancid.

Excipients: Oils for perfumery “Geissblat” №0764021, solid paraffin, Liquid paraffin, stearilstearat, mixture of emulsifiers “Rofetan GP”, white petrolatum, Purified water.

30 g – aluminum tuba (1) – packs cardboard.
50 g – aluminum tuba (1) – packs cardboard.
100 g – aluminum tuba (1) – packs cardboard.
250 g – banks polypropylene (10) – cardboard boxes.

Pharmacological action

Combined preparation for external use. It has antimicrobial, anti-inflammatory, immunostimulatory effects, improves tissue regeneration.

Bakteriocinы – polypeptides, produced by certain strains of bacteria and suppress the vital activity of bacteria of other strains of the same species or genetically related species of bacteria.

Piocinaza – thermostable mixture pyocyanin, alьfaoksifenazina, piolyuteorina and derivatives of 4-hydroxyquinoline. Prepared from Pseudomonas aeruginosa strains piotsinaza has an inhibitory effect on cocci bacteria and diphtheria. Pyocyanin is specific to the strains of Pseudomonas aeruginosa and has a pronounced antibacterial activity.

Soluble metabolites Staphylococcus spp., Streptococcus spp., Esherichia coli, Pseudomonas aeruginosa, canned phenol, inhibit the growth of the respective bacteria.

Zinc oxide has a moderate antimicrobial activity against pyrogenic Staphylococcus spp., Streptococcus spp., Pseudomonas aeruginosa, Candida albicans and dermatophytes. Zinc oxide absorbs tissue exudates.

Salicylic acid – antiseptic. It has also mestnorazdrazhayuschee, weak anti-inflammatory, analgesic and keratolytic action (softening and rejection of the horny layer of the epidermis); It helps remove microorganisms with the stratum corneum and better penetration to the affected area of ​​the other components Piolizina, which stimulate macrophages and granulocytes, producing connective tissue growth factor.

The filtrate of the culture medium of bacteria stimulates the non-specific defense reactions.

Pharmacokinetics

Distribution

When intact skin filtrate bacteria are not absorbed into the systemic circulation. Zinc oxide penetrates the skin, but it does not accumulate in the serum. Salicylic acid is absorbed in a small amount.

Metabolism

Salicylic acid is partially metabolized in the dihydroxybenzoic acid.

Deduction

Salicylic acid and its metabolite derived mainly kidneys.

Testimony

- Abscesses;

- Bedsores;

- Burns of all degrees;

- Wound infections;

- The difference of postoperative seams;

- Inflammation of the amputation stumps;

- Secondarily infected eczema;

- Acne;

- Festering skin;

- Inflammation of the sweat glands;

- Barley;

- Furunkul;

- Flegmona;

- Panaris;

- Hemorrhoids;

- Cracked skin foot;

- Leg ulcers;

- Impetigo;

- Otitis externa;

- Mastitis.

Dosage regimen

The ointment is applied in a thin layer to the affected skin 1-2 times / day.
Piolizin can be used in the form of ointment dressings.

Side effect

Maybe: allergic reactions.

Contraindications

- Idiosyncrasy.

Pregnancy and lactation

The drug should not be used in the breast during breast-feeding.

Cautions

–

Drug Interactions

Contact Piolizin ointments and petrolatum with latex condoms may decrease their strength and, Consequently, reduce the reliability of contraceptive action.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

Piolizin should be stored in a dry, protected from light, away from children at a temperature of 5 ° to 30 ° C. Shelf life – 3 year.