OKSAMP sodium

Active material: Oxacillin, Ampicillin
When ATH: J01CR50
CCF: Antibiotics penicillin broad spectrum, penicillinase-resistant
When CSF: 06.01.02.04.01
Manufacturer: SYNTHESIS JSC (Russia)

Pharmaceutical form, composition and packaging

Powder for solution for i / m administration white with a yellowish tint, hygroscopic.

Bottles (1) – packs cardboard.
Bottles (5) – packs cardboard.
Bottles (5) – contour cell package (1) – packs cardboard.
Bottles (5) – contour cell package (2) – packs cardboard.
Bottles (10) – packs cardboard.
Bottles (50) – cardboard boxes.

Pharmacological action

Combined antibacterial drug.

Oxacillin – an antibiotic from the group of semi-synthetic penicillins. Effective bactericidal, inhibiting the synthesis of bacterial cell wall. Resistant to penicillinase. Active against gram-positive bacteria: Staphylococcus spp. (incl. producing penicillinase), Streptococcus spp. (incl. Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis; Gram negative bacteria: Neisseria gonorrhoeae, Neisseria meningitidis; Anaerobic bacteria: spore-forming bacillus, Actinomyces spp. For oxacillin-resistant Gram-negative bacteria most, Rickettsia, viruses, protozoa, mushrooms.

Ampicillin – an antibiotic from the group of semi-synthetic penicillins. Effective bactericidal, inhibiting the synthesis of bacterial cell wall. Active against gram-positive bacteria: Staphylococcus spp. (except for strains, producing penicillinase), Streptococcus spp. (incl. Enterococcus spp.), nonspore bacteria (incl. Listeria monocytogenes); Gram-negative aerobic bacteria: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Shigella spp., Salmonella spp., Bordetella pertussis, some strains of Haemophilus influenzae.

Ampicillin destroyed by penicillinase.

The combination of ampicillin with oxacillin is rational, tk. latest, inhibiting the activity of penicillinase, thereby reducing the destruction of ampicillin. The spectrum of action in this combination becomes wider.

Pharmacokinetics

• Absorption

C_max active substances is achieved through 0.5-1 h after the / m. The on / in a fast blood are high concentrations, higher than those at the / m introduction.

• Distribution and excretion

During repeated administration of the active substances do not accumulate in the body, which makes it possible to use the drug for a long time. Excreted in the urine.

• Testimony
  • • respiratory tract infections (incl. bronchitis, pneumonia, bronchiectasis);
    • diseases of the biliary tract (incl. kholangit, cholecystitis);
    • urinary tract infections and kidney (incl. pyelitis, pyelonephritis, cystitis);
    • infections of skin and soft tissue (incl. infected wounds);
    • burn disease;
    • sore throat.

Prevention of postoperative complications in surgical interventions.

Prevention and treatment of infections in newborns.

Dosage regimen

The drug is administered / m or / (bolus or infusion).

Single dose for adults is 0.5-1 g, daily dose – 2-4 g.

Newborns, preterm infants and children under the age of 1 , the drug administered in a daily dose 100-200 mg / kg body weight; 1-7 years - 100 mg / kg / day; 7-14 years - 50 mg / kg / day; adolescents over 14 years prescribed dose for adults.

In severe infections these doses can be increased 1.5-2 times. The daily dose is administered in 3-4 receiving intervals 6-8 no. Duration of treatment 5-7 days before 3 weeks or more.

B / in the drug administered over 5-7 days followed (if necessary) on a / m introduction.

Terms of preparation and administration solutions

Solutions for i / m administration is prepared immediately prior to administration, adding to the contents of the vial 2 ml of sterile water for injection.

For in / infusion of the drug (single dose) dissolved in 10-15 ml of water for injection or isotonic sodium chloride solution and injected slowly over 2-3 m.

For in / drip drug for adults (single dose) dissolved in 100-200 ml of isotonic sodium chloride solution or 5-10% dextrose and is administered at a rate 60-80 drops / min. When drip children used as solvent 5-10% Dextrose (30-100 ml depending on the age).

Side effect

Allergic reactions: skin rash, hives, angioedema; rarely - anaphylactic shock.

Local reactions: at / in a possible development of phlebitis and periflebita; when i / m administration - pain at the injection site.

Contraindications

• hypersensitivity to the drug and other antibiotics of the penicillin group.

Pregnancy and breast-feeding

Perhaps the use of the drug Oksamp sodium during pregnancy if indicated. Excreted in breast milk in low concentrations.

Cautions

If you experience allergic reactions should stop administering the drug and conduct desensitizing therapy.

With the development of anaphylactic shock shows the introduction of epinephrine, GCS (gidrokortizon or prednisolone), bronchospasmolytics, histamine H1-receptor; If necessary, a ventilator.

Use in Pediatrics

With care should be prescribed to children, If the mother has a history of an indication of the increased sensitivity to penicillin. In such cases, if necessary, prescribing Oksamp sodium in the presence of comorbidities (bronchial asthma, hay fever and other allergic diseases) It shows the simultaneous use of antisense drugs.

Overdose

Currently, cases of drug overdose Oksamp sodium has not been reported.

Drug Interactions

There is a synergy of antibacterial action with a combination of the drug with bactericidal antibiotics – aminoglikozidami, cephalosporins, vancomycin, rifampicin.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

List B. The drug should be stored in a dry, protected from light, at room temperature. Shelf life – 2 year.