Ofloxacin
Active material: Ofloxacin
When ATH: S01AX11
CCF: Fluoroquinolone antibacterial drug for topical application in ophthalmology
ICD-10 codes (testimony): A74.0, H00, H01.0, H04.3, H04.4, H10.2, H10.4, H10.5, H16, H16.0, H16.2, Z29.2
When CSF: 06.17.02.03
Manufacturer: Synthesis of (Russia)
Pharmaceutical form, composition and packaging
Ophthalmic ointment 0.3% white, White with yellowish white or yellow.
| 1 g | |
| ofloxacin | 3 mg |
Excipients: nipagin (metilparagidroksiʙenzoat), nipazol (propilparagidroksibenzoat), vaseline.
5 g – aluminum tuba (1) – packs cardboard.
Pharmacological action
Antibacterial drug broad-spectrum fluoroquinolones from the group for local application in ophthalmology. Operates on DNK-girazu bacterial enzyme, provides sverhspiralizaciû and, thus, the stability of the DNA of bacteria (destabilization of the chains of DNA leads to death). Has bactericidal effect.
Vsokoakteven against gramotricatelnyh microorganisms: Pseudomonas aeruginosa, Escherichia coli, Salmonella spp., Proteus spp., Morganella morganii, Shigella spp., Klebsiella cloacae, Klebsiella spp., Enterobacter spp., Proteus is wonderful, Serratia spp., Citrobacter spp., Yersinia spp., Providencia spp., Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria meningitidis, Acinetobacter spp.; grampolozhitelnyh microorganisms: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus spp., Streptococcus pneumoniae, Streptococcus spp.; intracellular microorganisms: Chlamydia spp. (incl. Chlamydia trachomatis), Legionella spp., Mycoplasma spp.; anaerobes: Propionibacterium acnes.
Pharmacokinetics
IN experimental studies found, that after topical application of ofloxacin found in cornea (the cornea of the eye), conjunctivitis, eye muscles, the sclera, IRIS, ciliarnom the body and in the anterior Chamber of the eye.
Multiple use also leads to achieving therapeutic concentrations of ofloxacin in vitreous body. In the tissues of the eye creates a higher concentration of medicinal product, than in big watery eyes.
After a single application of strips of dressing up approximately 1 cm (roughly equivalent to 0.12 mg of ofloxacin) Cmax ofloxacin in the conjunctiva and sclera are achieved through 5 m, after which the concentration of ofloxacin is falling slowly. Cmax ofloxacin in big watery eyes and cornea is achieved through 1 no.
Testimony
-bacterial disease 21, the conjunctiva and cornea (bacterial keratitis and corneal ulcers, blepharitis, konъyunktyvytы, blefarokonjunktivity);
— mejbomit (barley), dakriocistit;
— hlamidiynye eye infection;
-Prevention of infectious complications in the postoperative period after surgical interventions over the removal of a foreign body and an eye injury.
Dosage regimen
Locally. For the lower lid of the affected eye 2-3 times/day lay 1 see strips of ointments (0.12 mg of ofloxacin). Hlamidiinah infections ointment 5-6 time / day.
For the imposition of ointment should be gently pull your lower eyelid down and, gently pressing down on the tube, enter in kongungualny bag striped dressing up 1 cm. Then close the lid and move the eye to distribute the ointment.
Duration of treatment is not more than 2 weeks (hlamidiinah infections rate extended to 4-5 weeks).
Side effect
Local reactions: burning sensation and discomfort in the eyes, hyperemia, itching and dryness of the conjunctiva, photophobia, lacrimation, allergic reactions. In most cases, these symptoms are brief.
Contraindications
-chronic non-bacterial conjunctivitis;
- Pregnancy;
- Lactation;
- Childhood and adolescence up 15 years;
- Hypersensitivity to the drug;
-hypersensitivity to other derivative hinolona.
Pregnancy and lactation
Do not use this drug during pregnancy and breastfeeding.
Cautions
Do not wear soft contact lenses during treatment with.
It is advisable to wear sunglasses (due to the possible development of photophobia), and avoid prolonged exposure to bright light.
Do not enter Ofloxacin subkongungualno or the eye's anterior Chamber.
Effects on ability to drive vehicles and management mechanisms
Immediately after use of the drug is possible ambiguity of visual perception, that could lead to difficulties when driving and when working with machinery. A smooth start to work (driving) through 15 minutes after treatment.
Overdose
The drug overdose data not provided.
Drug Interactions
When prescribing of Ofloxacin, along with other eye drops/ointments preparations should be applied at intervals of at least 15 m, and Ofloxacin should apply at least.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
List B. The drug should be stored out of reach of children at temperature from 15 ° to 25 ° C. Shelf life – 3 year.
