NORMAZE

Active material: Lactulose
When ATH: A06AD11
CCF: Laxatives osmotic properties. Gipoammoniemicheskoe means
ICD-10 codes (testimony): A02, K30, K59.0, K63, K72
When CSF: 11.08.03
Manufacturer: L. Molteni & C. Dei Fratelli Alitti Societa Di Esercizio s. p. a.. (Italy)

Pharmaceutical form, composition and packaging

◊ Syrup clear, colorless or light yellow with brownish tint, with a characteristic sweet smell.

Excipients: lemon acid, flavoring (No. 7 bis).

200 ml – vials of dark glass (1) complete with a measured glass – packs cardboard.

Pharmacological action

Laxative. It has hyperosmotic, gipoammoniemicheskoe, laxative effect, stimulates peristalsis, improves the absorption of calcium and phosphates.

Under the influence of the drug there is a change in the flora of the large intestine (increase in the number of lactobacilli), that leads to increased acidity in the lumen of the colon and stimulates irritative. Along with this increased volume and softening of stools. As a result, the drug has a laxative effect, without affecting directly the mucosa and smooth muscles of the colon. Under the influence of the drug the ammonia passes from the blood into the gut, This reduces the formation of nitrogen containing toxic substances in its proximal section and, respectively, vacuuming them in vena cava. Action can occur quickly or be delayed – through 24-48 no.

Has the ability to inhibit the growth of salmonella in the colon. It does not reduce the absorption of vitamins and is not addictive.

Pharmacokinetics

Low absorption.

Return via intestine unchanged, the kidney is excreted 3%.

Testimony

-chronic constipation;

Regulation Chair with haemorrhoids, need surgery on the colon and in the anal area, postoperatively;

is the liver precoma and coma;

- Hepatic encephalopathy;

-hyperammonemia;

-goiter;

-salmonellosis (except generalized forms);

syndrome gnilostna dispepsii resulting from food poisoning in young children.

Dosage regimen

The drug is taken orally after a meal.

At Garnishment adult first 3 days appoint 15-40 ml / day, then 10-25 ml / day. Children over 6 years -in the first 3 days appoint 15 ml / day, then- 10 ml / day, aged 1-6 years – 5-10 ml / day, aged 1 year – 5 ml / day. Duration of treatment 4 weeks before 3-4 Months.

At hepatic coma, precome, encephalopathy and hyperammoniemia the initial dose is at 30-60 ml 3 times / day. Then dose picked so, to soft Chair was 2-3 times / day. Treatment may continue until 3 months or more.

IN the postoperative period adult appoint 10-30 ml 3 times / day, older children 1 year - By 5-10 ml 2-3 times / day, aged 1 year - By 5 ml 2-3 times / day. The drug is prescribed by 18-24 h after surgery for 3-5 days.

Side effect

From the digestive system: flatulence, nausea, diarrhea.

When using the drug at high doses for a long time in the treatment of hepatic encephalopathy due to diarrhoea can develop violations vodno-elektrolitnogo Exchange.

Contraindications

-intolerance of Galactose or fructose;

- Galactosemia;

- Bowel obstruction;

-rectal bleeding (not hemorrhoidal);

-colostomy, ileostomy;

— suspected appendicitis;

- Hypersensitivity to the drug.

FROM caution use in patients with diabetes.

Pregnancy and lactation

Lactulose is safe to use in pregnancy and lactation (breast-feeding).

Cautions

With long-term use of the drug (more 6 Months) should regularly monitor the content of potassium, chlorine and carbon dioxide in the blood plasma.

When gastrocardiac syndrome should gradually increase the dose, to avoid flatulence.

Overdose

The drug overdose Normaze data not available.

Drug Interactions

Together with the use of antibiotics and antacids can reduce the effectiveness of lactoulozy.

Lactulose alters the pH-dependent release of kišečnorastvorimyh medicines. It is not recommended to take lactoulozu during 2 hours after administration of other drugs.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at temperature from 15 ° to 25 ° C. Shelf life - 3 year.