Active material: Drotaverine
When ATH: A03AD02
CCF: Myotropic antispasmodic
ICD-10 codes (testimony): G45, I73.9, K25, K26, K29, K31.3, K52, K81.0, K81.1, K82.8, K91.5, N20, N21, N23, N94.4, N94.5, O62, Z29.8
When CSF: 01.14.05
Manufacturer: CHINOIN Pharmaceutical and Chemical Works Co. Ltd. (Hungary)
◊Pills convex, oblong, yellow with a greenish or orange tint, на одной стороне маркировка “NOSPA”, на другой – риска.
| 1 tab. | |
| Drotaverine hydrochloride | 80 mg |
Excipients: magnesium stearate, talc, povidone, corn starch, lactose.
10 PC. – блистеры (2) – пачки картонные.
Myotropic antispasmodic. On chemical structure and pharmacological properties similar to papaverine, but has a strong and long-acting. Reduce intake of calcium in the smooth muscle cells (It inhibits phosphodiesterase, It leads to the accumulation of intracellular cAMP). It reduces the tone of smooth muscles of internal organs and intestinal peristalsis, dilates blood vessels.
No effect on the autonomic nervous system, It does not penetrate the CNS.
Have a direct effect on the smooth muscles of the drug can be used as an antispasmodic in cases, when contraindicated drugs from the group of m-holinoblokatorov (zakrыtougolynaya glaucoma, prostate adenoma).
Absorption
If ingestion drotaverine rapidly absorbed from the gastrointestinal tract, период полуабсорбции – 12 m. Bioavailability - approx. 100%. Cmax in serum obtained through 2 no.
Distribution
Plasma protein binding - 95-98%. Evenly distributed in the tissues, It penetrates into the smooth muscle cells. Drotaverine does not penetrate the blood-brain barrier.
Deduction
Excreted in the urine, в меньшей степени – с желчью.
- Prevention and treatment of functional disorders and pain, induced smooth muscle spasm (incl. in chronic gastroduodenitis, chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, gastric ulcer and duodenal ulcer, spasms of the pyloric and gastric cardia, spasticheskom cars, urolithiasis);
- Algomenorrhea;
- To weaken uterine contractions and cervical spasm relief in labor;
- Spasms of peripheral arterial disease, cerebrovascular;
- Prevention of smooth muscle spasm during the instrumental studies.
The drug is prescribed inside adult by 40-80 mg (1/2-1 tab.) 2-3 times / day; children aged 6 to 12 years - By 20 mg (1/4 tab.) 1-2 times / day.
Maybe: dizziness, palpitations, decrease in blood pressure, feeling the heat, increased sweating, allergic skin reactions.
- Severe hepatic impairment;
- Expressed by the human kidney;
- Severe heart failure;
— AV-blockade II and III degrees;
- Cardiogenic shock;
- Hypotension;
- Hypersensitivity to the drug.
FROM caution prescribe the drug to patients with severe coronary atherosclerosis, BPH, glaukomoj, Pregnancy and lactation.
Precautions should be prescribed the drug during pregnancy. During the period of lactation (breast-feeding) appoint drotaverine not recommended due to the lack of clinical data.
–
In high doses, it violates AV-conduction, reduces the excitability of cardiac muscle, can cause heart failure and paralysis of the respiratory center.
At simultaneous application But-spa® Forte could weaken the antiparkinsonian effect of levodopa.
At simultaneous application But-spa® Fort enhances the effect of papaverine, bendazol and other antispasmodics (incl. Mr. holinoblokatorov).
In an application with Nospanum® Fort tricyclic antidepressants, quinidine and procainamide enhanced hypotensive effect.
At simultaneous application But-spa® Fort reduces the activity of morphine spasmogenic.
With simultaneous use of phenobarbital increases the severity of antispasmodic action drotaverine.
The drug is resolved to application as an agent Valium holidays.
List B. The drug should be stored out of reach of children at temperature from 15 ° to 25 ° C. Shelf life - 5 years.
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