Nimesulide

When ATH:
M01AX17

Pharmacological action

Anti-inflammatory, pyretic, analgesic.

Application

Osteoarthritis (incl. rheumatoid arthritis), osteoarthritis, ʙursit, Tendinitis, pain and inflammation processes (incl. trauma, postoperatively, gynecological and infectious and inflammatory diseases).

Contraindications

Hypersensitivity (incl. to other NSAIDs), severe bleeding in the digestive tract, gastric ulcer or duodenal ulcer in the acute stage, expressed human liver and kidneys (if Cl creatinine less than 30 ml / min), pregnancy, lactation.

Restrictions apply

Childhood (to 12 years).

Pregnancy and breast-feeding

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Side effects

From the nervous system and sensory organs: seldom - a headache, dizziness, drowsiness.

Cardio-vascular system and blood (hematopoiesis, hemostasis): very rarely - thrombocytopenia.

From the digestive tract: rarely - nausea, heartburn, stomach ache, tarry stools, ground.

For the skin: rarely - petechiae, purpura.

With the genitourinary system: rarely - oliguria.

Allergic reactions: rash, эritema, hives.

Cooperation

Can enhance the efficacy and toxicity of many drugs, as a result of their displacement from binding sites to plasma proteins and increase the free fraction of blood (while the appointment of hydantoin and sulfonamides requires regular medical supervision). It enhances the effect of drugs, reduce blood clotting; increases in plasma levels of lithium.

Overdose

Symptoms: increased severity of side effects.

Treatment: gastric lavage, appointment of activated carbon.

Dosing and Administration

Inside, after meal, adults only, by 100 mg 2 once a day.

Precautions

Be wary appoint elderly patients, cardiovascular diseases, including hypertension, propensity to bleed, disorders of the upper gastrointestinal, renal impairment (recommended dose reduction), during treatment with anticoagulants and antiplatelet. When the blurred vision, stop taking the drug and consult an eye specialist. Patients with diabetes and patients, which keep low-calorie diet, should be considered, that is formulated with sucrose. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.