NAZIVIN

Active material: Oksimetazolin
When ATH: R01AA05
CCF: Vasoconstrictor drugs for local application in an ENT-practice
ICD-10 codes (testimony): H66, H68, J00, J01, J30.0, J30.1, J30.3, Z51.4
At KFU: 24.05.01
Manufacturer: MERCK KGaA (Germany)

Pharmaceutical form, composition and packaging

◊ Nasal drops as a nearly transparent, colorless to slightly yellowish solution.

Excipients: benzalkonium chloride 50% solution, disodium эdetat digidrat, sodium dihydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium hydroxide solution 1 M, Purified water.

5 ml – vials of dark glass with a lid, pipetted (1) – packs cardboard.

◊ Nasal drops as a nearly transparent, colorless to slightly yellowish solution.

Excipients: benzalkonium chloride 50% solution, disodium эdetat digidrat, sodium dihydrogen phosphate dihydrate, sodium hydroxide solution 1 M, Purified water.

10 ml – vials of dark glass with a lid, pipetted (1) – packs cardboard.

◊ Nasal drops as a nearly transparent, colorless to slightly yellowish solution.

Excipients: benzalkonium chloride 50% solution, disodium эdetat digidrat, sodium dihydrogen phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium hydroxide solution 1 M, Purified water.

10 ml – vials of dark glass with a lid, pipetted (1) – packs cardboard.

Pharmacological action

Vasoconstrictor drugs for local use, alpha₂-adrenomimetik.

When applied topically on inflamed mucous membranes of the nose and reduces their swelling amount of bleeding. Restores nasal breathing. By eliminating the swelling of the mucous membranes, medication helps to restore the aeration of the paranasal sinuses, middle ear cavity and preventing the development of bacterial complications (gaimorita, sinusitis, otitis media).

For topical intranasal application of therapeutic concentrations oxymetazoline has no systemic action, It does not irritate the mucous membranes and causes hyperaemia.

The drug takes effect within minutes.

Duration of up to 12 no.

Pharmacokinetics

The data on the pharmacokinetics Nazivin^® not provided.

Testimony

- Treatment of acute respiratory infections, accompanied by rhinitis;

- Allergic rhinitis;

- Vasomotor rhinitis;

- The restoration of drainage in the sinuses inflammation of the nasal cavity, evstahiite, otitis media;

- The elimination of edema to diagnostic procedures in the nasal passages.

Dosage regimen

Drops Nazivin^® designed to receive the nose.

Adults and children over 6 years should be prescribed drops 0.05% by 1-2 drops in each nostril 2-3 times / day.

Children aged 1 Year to 6 years should be prescribed drops 0.025% by 1-2 drops in each nostril 2-3 times / day.

Children under 1 year prescribe drops 0.01%. Newborns (children under the age of 4 weeks) administered by 1 drop in each nostril 2-3 times / day. Children aged 1 Months before 1 year appoint 1-2 drops in each nostril 2-3 times / day. To ensure accurate dosage vial drops 0.01% It has graduated pipette stamped number drops. If appointed 1 drop, the pipette should be filled with a solution to the mark 1.

The efficiency is also following procedure: depending on the age 1-2 drops 0.01% the solution is applied to the cotton and wipe the nasal passages.

Nazivin should be used for 3-5 days. Doses, exceeding recommended, appointed at the discretion of the physician.

Side effect

Local reactions: sometimes – dryness and burning sensation of the nasal mucosa, chikhaniye, rarely (after the end of Nazivin^®) – a feeling of nasal congestion (reaktivnaя giperemiя).

CNS: rarely – anxiety, insomnia, fatigue, headache.

From the digestive system: rarely – nausea.

Cardio-vascular system: if multiple possible overdose hypertension, tachycardia.

Long continuous use of vasoconstrictor drugs can lead to tachyphylaxis, atrophy and return swelling of the mucous membranes of the nasal cavity (drug-induced rhinitis).

Contraindications

- Atrophic rhinitis;

- Zakrыtougolynaya glaucoma;

- Hypersensitivity to the drug.

It should adhere to the recommended concentrations of the drug, designed for different age groups (cm. methods of using).

FROM caution should be used, while the use of MAO inhibitors and other drugs, help improve blood pressure, as well as in the period before 10 days after discontinuation of these drugs; at elevated intraocular pressure; Pregnancy and lactation; in severe forms of heart disease (arterial hypertension, angina); thyrotoxicosis and diabetes.

Pregnancy and lactation

Use of the drug during pregnancy and lactation is possible only after careful evaluation of the benefit ratio for the mother and the risk to the fetus or infant. It is unacceptable excess of the recommended dose.

Cautions

Avoid long-term use and overdose, especially in children.

Effects on ability to drive vehicles and management mechanisms.

After prolonged use of drugs, containing oxymetazoline, at dosages, exceeding recommended, we can not exclude the overall impact on the cardiovascular system and central nervous system (In these cases, the ability to operate a vehicle or equipment may be reduced).

Overdose

Symptoms: with a significant overdose or ingestion may occur pupillary, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, collapse, oppression heart, arterial hypertension, pulmonary edema, respiratory disorders. Besides, may experience mental disorders, as well as inhibition of the central nervous system, accompanied by sleepiness, declination of fever, ʙradikardiej, hypotension, respiratory failure, and the possible development of coma.

Treatment: gastric lavage, administration of activated charcoal.

Drug Interactions

In an application Nazivin^® MAO blockers or tricyclic antidepressants observed increase in blood pressure.

Co-administration of other vasoconstrictor drugs increases the risk of side effects.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C. Shelf life – 3 year.