Oksimetazolin (When ATH R01AA05)

When ATH:
R01AA05

Characteristic.

Oxymetazoline hydrochloride is freely soluble in water, alcohol. Practically insoluble in ether, xloroforme, benzene. Molecular weight 296,84.

Pharmacological action.
Alfa adrenomimeticheskoe, vasoconstrictor, antikongestivnoe.

Application.

Coryza (incl. allergic), vasomotor rhinitis, paranazalinyi sinusitis, evstahiit, otitis media; for mucosal vasoconstriction diagnostic purposes (under the supervision of a physician).

Contraindications.

Hypersensitivity, incl. other decongestants for nasal application; atrophic rhinitis, zakrыtougolynaya glaucoma, arterial hypertension, expressed atherosclerosis, irregular heartbeat, congestive heart failure, diabetes, thyrotoxicosis, Children up to age 1 year (drip 0, 025 and 0,05%), Children up to age 6 years (dlya spray 0,05%).

Pregnancy and breast-feeding.

During pregnancy and breastfeeding is not allowed to exceed the recommended dosage. Application possible after careful evaluation of the ratio of benefits to the mother and the risk to the fetus or child.

Side effects.

Local reactions: dryness and burning sensation of nasal mucosa, dry mouth or throat, chikhaniye, "Rebound" swelling of the mucous membrane (increased secretions from the nose or nasal congestion).

Systemic effects: sleep disturbance, excitation, increased anxiety, dizziness, headache, heartbeat, nausea, increased blood pressure.

Other: taxifilaksija, reactive hyperemia of the mucosa and atrophy of the nasal mucosa (prolonged use).

Cooperation.

It slows the systemic absorption of local anesthetics and prolong their effects. The combined use with other vasoconstrictor drugs increases the risk of side effects. With simultaneous use of oxymetazoline and MAO inhibitors or tricyclic antidepressants may increase blood pressure.

Overdose.

Symptoms (after a significant overdose or accidental ingestion): pupillary constriction, nausea, vomiting, cyanosis, fever, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest; Besides, may appear mental disorders, as well as inhibition of the central nervous system, accompanied by sleepiness, declination of fever, ʙradikardiej, hypotension, respiratory failure, and the possible development of coma.

Treatment: gastric lavage, administration of activated charcoal, an urgent appeal to the doctor, simptomaticheskaya therapy.

Dosing and Administration.

Intranasal: adults and children over 12 years 1-2 drops 0.05-0.025% solution into each nasal passage 2-3 times a day or 2-3 injection 0,05% spray; children 6-12 years - 1 injection into each nostril. Re-introduction possible through 10-12 h. The duration of no more than 3-5 days; if necessary, further treatment is necessary to consult with your doctor.

Precautions.

The children can be increased absorption into the blood oxymetazoline, leading to the development of side effects.

After prolonged use of funds from the cold, containing oxymetazoline, at dosages, exceeding recommended, we can not exclude the overall impact on the cardiovascular system and central nervous system. In these cases, the ability to operate a vehicle or equipment may be reduced.