N-AC-Ratiopharm

Active material: Acetylcysteine
When ATH: R05CB01
CCF: Mucolytic drugs
When CSF: 12.02.01
Manufacturer: ratiopharm GmbH (Germany)

Pharmaceutical form, composition and packaging

[Ring] Citric acid anhydrous, natriya carbonate, lemon flavor, the fine adipic acid, povidone, Aspartame.

10 PC. – Plastic Packaging (1) – packs cardboard.
10 PC. – Plastic Packaging (2) – packs cardboard.
20 PC. – Plastic Packaging (1) – packs cardboard.
20 PC. – Plastic Packaging (2) – packs cardboard.

Pharmacological action

Acetylcysteine ​​exhibits secretolytic and sekretomotornym action in the bronchial tract. Phlegm, increasing its volume, facilitates its separation. It retains its activity in the presence of purulent sputum. The mechanism of action is based on the ability of acetylcysteine ​​sulfhydryl groups to break disulfide bonds of acid mucopolysaccharides sputum, which leads to depolarization and mucoproteins decrease mucus viscosity.

It promotes synthesis of glutathione, which is an important factor for intracellular antioxidant protection and allows maintaining functional activity and morphological integrity of the cells, what, in particular, It explains its effectiveness as an antidote for poisoning by paracetamol.

The therapeutic effect is observed after 30-90 minutes and persists for 2-4 no.

Indications for use of the drug

Respiratory diseases and condition, accompanied by the formation of a viscous trudnootdelyaemoy muco-purulent sputum:

• acute and chronic bronchitis;
• due to bacterial tracheitis and / or viral infections;
• Bronchiolitis;
• pneumonia;
• bronchial asthma;
• bronchiectasis;
• atelectasis due to blockage of the bronchi mucous plug;
• mukovystsydoz (in a combination therapy);
• removal of viscous secretions from the respiratory tract in post-traumatic and postoperative conditions;
• facilitating mucus secretion and sinusitis.

Dosage regimen

Inside, after meal, after dissolving the powder in a glass of water. Normally, we recommend the following dosage: adults and adolescents over 14 years: 400-600 mg /, podelennыe of 2-3 admission; older children 6 years: 400 mg /, podelennыe of 2-3 admission; children aged 2 to 6 years: 200 acetylcysteine ​​mg per day, podelennыe of 2-3 admission.

Newborns are used only for health reasons in the dose 10 mg / kg of body weight under strict medical supervision. Babies first year of life resulting solution allowed to drink from a spoon or a feeding bottle. Children from 1 Year to 2 years (only under strict medical supervision) appointed 100-200 mg /, podelennыe of 2-3 admission.

Cystic Fibrosis Treatment. Children over 6 appoint years 600 mg /, podelennыe of 3 admission; Children from 2 to 6 years: 400 mg /, podelennыe of 4 admission, infants from the 10th day of life, and children up to 2 years: 100-150 mg /, podelennыe of 2-3 admission under strict medical supervision.

Duration (continuity) use depends on the specific disease. In the treatment of chronic bronchitis and cystic fibrosis treatment can be lengthy (up to several months).

Side effect

• From the digestive system: rarely – heartburn, nausea, vomiting, diarrhea, a feeling of fullness.

Allergic reactions: rarely – skin rash, itch, hives, bronchospasm.

Other: rarely – nosebleeds, noise in ears, drowsiness, fever.

If you have any undesirable side effects, seek medical advice.

Contraindications

• known hypersensitivity to acetylcysteine ​​or any other ingredients of the formulation;
• gastric ulcer and duodenal ulcer in the acute phase;

Carefully: bronchial asthma; liver disease; kidney disease; adrenal disease; esophageal varices; arterial hypertension; propensity to pulmonary hemorrhage, hemoptysis; Children up to age 2 years.

Infants and children up to 2 years may be imposed only for health, under steady state conditions and by direct medical supervision at a dose 10 mg / kg body weight.

Pregnancy and lactation

Use of the drug during pregnancy and lactation is possible only in the case, if the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Application for violations of liver function

Be wary of liver zabolevanieyah.

Application for violations of renal function

Be wary of kidney zabolevanieyah.

Cautions

In applying the drug in patients with bronchial asthma need to provide drainage of mucus, combined with bronchodilators.

During the period of use of the drug patients are encouraged excessive fluid intake, that the effect of the drug support secretolytic. In applying the drug must be used glassware, Avoid contact of the product with metals, Rubber, oxygen, easily oxidized substances.

Patients with diabetes should be aware, one bag (sachet) 100 mg comprises 1.85 g carbohydrates, and one bag (sachet) 200 mg comprises 1.75 g carbohydrates, which corresponds to approximately 0.15 HE.

Overdose

So far, cases of drug overdose with oral acetylcysteine ​​is not described.

Symptoms: Accidental taking very large doses may be nausea, vomiting, diarrhea.

Treatment: symptomatic.

Drug Interactions

With simultaneous use of acetylcysteine ​​and antitussives may increase the stagnation of phlegm due to suppression of the cough reflex, therefore, such a combined treatment should be carried out only under the direct supervision of a doctor.

There is evidence, acetylcysteine ​​that the thiol group can neutralize the activity of certain antibiotics (Amphotericin B, ampicillin, tetracikliny, isklюchaя doxycycline, semisynthetic penicillins, cephalosporins, aminoglikozidy). Therefore, it is appropriate to oral administration of antibiotics through 2 hours after receiving acetylcysteine.

It was also established, antibiotics such as amoxicillin, doxycycline, Erythromycin, triamterene, Cefuroxime not interact with acetylcysteine. Acetylcysteine ​​reduces gepatotoksičeskoe action of paracetamol.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

Store at temperatures not above 25 ° C, out of reach of children.

Shelf life – 5 years.

Do not use after the expiry, on the package.