Acetylcysteine

When ATH:
R05CB01

Characteristic.

White or white with a slightly yellowish white crystalline powder, with low specific smell. The easily soluble in water and alcohol; pH 20% aqueous 7-7.5.

Pharmacological action.
Mucolytic, expectorant, gepatoprotektivnoe, detoxifying.

Application.

Cough phlegm (bronchitis, pneumonia, bronchiectasis), bronchial asthma, cystic fibrosis of the lung, otitis, rhinitis, sinusitis, complications from the operations in the respiratory organs (prevention), paracetamol poisoning (as an antidote).

Contraindications.

Hypersensitivity, gastric ulcer and duodenal ulcer in the acute stage, propensity to pulmonary hemorrhage, hemoptysis, pneumorrhagia, bronchial asthma (without dramatizing mucus), liver disease, kidney, adrenal.

Pregnancy and breast-feeding.

Category actions result in FDA - B. (The study of reproduction in animals revealed no risk of adverse effects on the fetus, and adequate and well-controlled studies in pregnant women have not done.)

Side effects.

Heartburn, nausea, vomiting, noise in ears, hives.

Cooperation.

Increases (mutually) effect of bronholitikov. Decreases induction penitsillinov, cephalosporins, tetracyclines (interval between doses should be at least 2 no). Farmatsevticeski incompatible with antibiotics and proteoliticakimi enzymes; upon contact with metals, rubber forms sulphides with a characteristic smell.

Dosing and Administration.

Inside. For acute diseases adults and adolescents older than 14 years is 400-600 mg/day 1 or 2 admission. Under dose for children (take 2-3 times a day) It depends on the age: c 2 Sun to 2 years - 50 mg; to 6 years - 100 mg, to 14 years - 200 mg (no more 400 mg / day); the course is 5-7 days.

In chronic diseases within a few weeks: adults — 400-600 mg/day 1 or 2 admission; children 6-14 years are 100 mg 3 once a day.

In cystic fibrosis: Children from 10 days of life before 2 years - 50 mg 3 once a day, 2-6 years 100 mg 4 once a day, senior 6 years - 200 mg 3 once a day.

Patients weighing more than 30 kg can be increased dose to 800 mg / day.

/ M, adult on 300 mg 1 once a day, children - 150 mg 1 once a day, infants — on 10-15 mg/kg 2 once a day.

Inhalation, on 2-5 ml 20% Solution 3-4 times a day (for 15-20 minutes).

Vnutritrahealno, by 1 ml 10% solution every hour (in the form of slow instillation).

Locally, for washing the auditory passages, the nasal passages (on 1 guaranteed-1.5-3 ml 10% solution).

Precautions.

In patients with bronhoobstruktive syndrome (develops fairly often with increased bronchospasm) acetylcysteine needs to be combined with bronholitikami.

Cautions.

It should not be allowed contact with metals, Rubber, oxygen, easily oxidized substances.