Active material: Benfotiamin, Pyridoxine
When ATH: A11DB
CCF: The complex B vitamins
ICD-10 codes (testimony): B02.2, G50.0, G51, G60, G61, G62.1, G63.2, H46, M54.1, M54.3, M54.4, M79.2, R25.2
At KFU: 02.11.01
Manufacturer: WÖRWAG PHARMA GmbH & Co. KG (Germany)
Drop white, round, lenticular.
| 1 drop | |
| ʙenfotiamin | 100 mg |
| pyridoxine hydrochloride (wreathed. B6) | 100 mg |
Excipients: microcrystalline cellulose, povidone (K-30), trigliceridy (Omega 3, 20%), colloidal silicon dioxide, carmellose sodium, talc, shellac, sucrose, calcium carbonate, acacia, corn starch, Titanium dioxide, macrogol 6000, glycerol 85%, polysorbate 80, Mining glycol wax.
15 PC. – упаковки ячейковые контурные (2) – пачки картонные.
15 PC. – упаковки ячейковые контурные (4) – пачки картонные.
Vitamin products the combined structure. Neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and musculoskeletal system. Contribute to increased blood flow, and improve the functioning of the nervous system.
Бенфотиамин – жирорастворимый аналог витамина В1 (tiamina). Thiamine plays a key role in the metabolism of carbohydrates, and in the Krebs cycle, followed in the synthesis TPF (thiamine pyrophosphate) and ATP (adenosine triphosphate).
Pyridoxine (vitamin B6) involved in the metabolism of protein, and partially, in the metabolism of carbohydrates and fats.
The physiological function of both vitamins is potentiation of each other, It manifests itself in a positive impact on the nervous, neuromuscular and cardiovascular systems. At deficiency of vitamin B6 widespread state deficit quickly cease after the application of these vitamins.
Distribution
In the body, thiamine unevenly distributed at a content in leukocytes 15%, erythrocytes 75% in plasma 10%. Thiamine penetrate the BBB and placental barrier, excreted in breast milk.
Pyridoxine is absorbed into the bloodstream and distributed in the body, acting as a coenzyme after phosphorylation group CH2OH 5-position. About 80% Vitamin bound to plasma proteins. Pyridoxine is distributed throughout the body, It crosses the placental barrier, excreted in breast milk.
Metabolism
The main metabolites are thiamine: tiaminkarbonovaya acid, Pyramin and some unknown metabolites. Of all the vitamins thiamine stored in the body in the least amount. The body of an adult contains about 30 mg thiamine: in the form of thiamine pyrophosphate (80%), thiamine triphosphate (10%) and a remaining amount of thiamine monophosphate.
Pyridoxine deponiruetsя in baked and okislяetsя to 4 piridoksinovoй kislotы.
Deduction
Thiamine is excreted in the urine in the α-phase through 0.15 no, в β-фазе – через 1 ч и в терминальной фазе – в течение 2 days.
4-pyridoxine acid is excreted in the urine, a maximum of 2-5 h after absorption.
As a pathogenetic and symptomatic treatment in the complex treatment of neurological diseases and syndromes of different origin:
- Neuralgia;
- Neuritis;
- Paresis of the facial nerve;
- Optic neuritis;
- Ganglionitis (including herpes zoster);
- Plexopathy;
- Neuropathy;
- Polyneuropathy (incl. Diabetic, Alcoholic);
- Nocturnal muscle cramps (particularly in older age groups);
- Neurological manifestations of osteochondrosis;
- Radikulopatiya;
- Ljumʙoişialgija;
- Muscular-tonic syndromes.
If all indications appoint 1 Pills to 3 times / day for 1-1.5 Months.
Allergic reactions: possible urticaria, labored breathing, angioedema, anaphylactic shock.
Dermatological reactions: в отдельных случаях – повышенное потоотделение, acne, itch.
Other: в отдельных случаях – тахикардия.
- Decompensated heart failure;
- Children's age;
- Hypersensitivity to the drug.
We do not recommend the use of the drug during pregnancy and lactation (breast-feeding).
There is no clinical experience with the drug Milgamma® kompozitum in pediatrics.
Treatment: gastric lavage, administration of activated charcoal, symptomatic therapy.
Levodopa reduces the effectiveness of vitamin B6 at therapeutic doses.
As a result of interaction with cycloserine, D-penïcïllamïnom, epinephrine, norepinephrine, sulьfonamidami, may decrease the effectiveness of pyridoxine.
Thiamine is completely destroyed in solutions, containing sulfites. Other vitamins are inactivated in the presence of decomposition products of vitamin B.
Thiamine is incompatible with oxidizing substances, mercuric chloride, iodide, karʙonatom, acetate, tannic acid, hardware-ammonium citrate, and takzhe fenobarbitalom, riʙoflavinom, benzilpenicillinom, dextrose and sodium metabisulphite.
Copper accelerates the destruction of thiamine.
Thiamine loses activity with increasing pH (more 3).
The drug is released under the prescription.
The drug should be stored out of reach of children at or above 25 ° C. Shelf life - 5 years.
This site uses cookies and services to collect technical data from visitors to ensure performance and improve the quality of service.. By continuing to use our site, you automatically agree to the use of these technologies.
Read More