MIDOLAT
Active material: Meldonium
When ATH: C01EB
CCF: Preparation, improves metabolism and energy supply of tissues
ICD-10 codes (testimony): F10.3, G45, I10, i20, I21, I42, I50.0, I61, I63, I67.2, I69, Z54, Z73.0, Z73.3
When CSF: 01.12.11.05
Manufacturer: OLINEFARM AS (Latvia)
Pharmaceutical form, composition and packaging
Capsules hard gelatin, size №1, white/white; contents of capsules – white powder.
| 1 caps. | |
| Meldonia dihydrate | 250 mg |
Excipients: potato starch, colloidal silicon dioxide, calcium stearate.
Ingredients of the capsule shell: gelatin, Titanium dioxide (E171).
10 PC. – blisters (2) – packs cardboard.
10 PC. – blisters (4) – packs cardboard.
Pharmacological action
Preparation, improves metabolism and energy supply of tissues. Midolat – analog of gamma-butyrobetaine, The gamma-butygotagidoxinase suppresses, reduces the synthesis of carnitine and transport of long -chain fatty acids through cell membranes, prevents accumulation in cells activated forms of oxygenated fatty acids – acylcarnitine derivatives and atsilkoenzima A. The ischemia restores equilibrium processes oxygen delivery and consumption in cells, prevents vehicle violation of adenosinitrifosphoric acid; simultaneously activates glycolysis, Klno is flowing without additional oxygen consumption. As a result of a decrease in carnitine concentration, the synthesis of gamma-butybutaine is enhanced, which has vasodilating properties.
The mechanism of action determines the variety of pharmacological effects: increase efficiency, reducing the symptoms of the mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect. In the case of acute ischemic myocardial damage slows the formation of necrotic zone, shortens the rehabilitation period. In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, It promotes redistribution of blood to the ischemic area. Effective in the case of vascular and dystrophic pathology of the fundus. The tonic effect on the central nervous system is also characteristic, elimination of functional disorders of somatic and autonomic nervous systems in patients with chronic alcoholism during the period of withdrawal.
Pharmacokinetics
Absorption
After intake of rapidly absorbed, bioavailability – 78%. Cmax plasma levels achieved after 1-2 hours after ingestion.
Metabolism
It is metabolized in the body into two major metabolites, that the kidneys. T1/2 When taking orally, it depends on the dose and makes up 3-6 no.
Testimony
- in neurology in complex therapy: ischemic stroke, hemorrhagic stroke in the recovery period, transient ischemic attacks, chronic cerebrovascular failure;
- in cardiology in complex therapy: CHD (angina, myocardial infarction), congestive heart failure, Dysgormonal cardiomyopathy;
- Reduced performance; physical strain, incl. athletes; postoperative period to accelerate the rehabilitation;
- withdrawal alcoholic syndrome (in combination with specific therapy).
Dosage regimen
The drug is prescribed inside.
At violation of cerebral circulation in the acute phase Apply the injection form of the drug during 10 days, After that, the drug is prescribed inside 500 mg / day. A course of treatment – 4-6 weeks.
At chronic disturbances in cerebral circulation – by 500 mg 1 time / day, preferably in the first half of the day. A course of treatment – 4-6 weeks. Repeated courses – 2-3 per year.
IN Cardiology in complex therapy – by 0.5-1 g / day. A course of treatment – 4-6 weeks.
At cardialgia on background dyshormonal myocardial dystrophy – by 250 mg 2 times / day (in the morning and in the evening). A course of treatment – 12 days.
At mental and physical overload (incl. athletes) adult – by 250 mg 4 times / day. A course of treatment – 10-14 days. If necessary, treatment is repeated through 2-3 of the week.
Before training – by 0.5-1 g 2 times / day, preferably in the first half of the day. Duration of the course during the preparatory period – 14-21 day, during the competition – 10-14 days.
At alcohol withdrawal syndrome – by 500 mg 4 times / day. A course of treatment – 7-10 days.
Side effect
Rarely: allergic reactions (itching, rashes, redness and swelling of the face), dyspepsia, tachycardia, excitation, decrease in blood pressure.
Contraindications
- Increased intracranial pressure (In case of violation of venous outflow and intracranial tumors);
- Pregnancy;
- Lactation (breast-feeding);
- Children up to age 18 years;
- Hypersensitivity to the drug.
Pregnancy and lactation
The drug is contraindicated in pregnancy and during breastfeeding.
Cautions
With caution, the drug is prescribed for diseases of the liver and /or kidneys.
Effects on ability to drive vehicles and management mechanisms
There is no data on the adverse effects of the drug on the ability to drive vehicles.
Overdose
Случаи передозировки не установлены.
Drug Interactions
Не применять одновременно с другими лекарственными формами, содержащими мельдоний (риск развития побочных действий).
Enhances the effect of coronary and some antihypertensive agents, cardiac glycosides.
In view of the possible development of moderate tachycardia and arterial hypotension, Caution should be observed with a combination with nitroglycerin, nifedipine, Alpha-blockers, antihypertensive drugs and peripheral vasodilators.
Can be combined with antianginal drugs, anticoagulants, antiplatelet, antiarrhythmic drugs, Diuretics, bronholitikami.
Conditions of supply of pharmacies
The drug is released under the prescription.
Conditions and terms
List B. The drug should be stored in a dry, out of the reach of children at a temperature of no higher than 25° c. Shelf life – 2 year.
