Meldonium

When ATH:
C01EB

The pharmacological action of mel′doniâ

Means, improve metabolism, analog of gamma-butyrobetaine. Suppresses gamma butirobetaingidroksinazu, inhibits the synthesis of carnitine and transport of long-chain fatty acids through cell membranes, prevents accumulation in cells activated forms of oxygenated fatty acids – acylcarnitine derivatives and atsilkoenzima A.

The ischemia restores equilibrium processes oxygen delivery and consumption in cells, to prevent violations of transport ATP; simultaneously activates glycolysis, which proceeds without additional consumption of oxygen. As a result of reducing the concentration of carnitine is synthesized hard gamma-butyrobetaine, vasodilating properties. The mechanism of action determines the diversity of its pharmacological effects: increase efficiency, reducing the symptoms of the mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect.

In the case of acute ischemic myocardial damage slows the formation of necrotic zone, shortens the rehabilitation period. In heart failure, increases myocardial contractility, increases exercise tolerance, reduces the frequency of angina attacks. In acute and chronic ischemic cerebrovascular disorders improves blood circulation in the ischemic focus, It promotes redistribution of blood to the ischemic area. Effective with vascular and dystrophic pathology of the fundus. It has a tonic effect on the CNS, eliminates functional disorders of the nervous system in patients with chronic alcoholism during abstinence syndrome.