Meldonium

Pharmacokinetics mel′doniâ

After intake of rapidly absorbed from the gastrointestinal tract. Bioavailability is about 78%. Cmax in plasma achieved through 1-2 h after administration. Biotransformed in the body to form two major metabolites, that the kidneys. T1 / 2 is 3-6 hours and was dose-dependent.

Indications for use mel′doniâ

For intake or / in the introduction: in the complex treatment of coronary artery disease (angina, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy; in the complex therapy of acute and chronic disorders of cerebral circulation (strokes and cerebrovascular insufficiency); reduced working capacity, physical strain (incl. athletes), postoperative period to accelerate the rehabilitation; abstinence syndrome in chronic alcoholism (in combination with a specific treatment of alcoholism).

For parabulbarnom: acute circulatory disorder in the retina, hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (incl. Diabetic and hypertensive) – only parabulbarnom.