Midekamicin

When ATH:
J01FA03

Characteristic.

Macrolide antibiotics.

Pharmacological action.
Antibacterial.

Application.

Respiratory tract infections and urinary tract, caused intracellular microorganism. Respiratory Tract Infections, Skin and subcutaneous tissue, caused by bacteria susceptible to penicillin, for the treatment of patients with a hypersensitivity to penicillin. Enteritis, caused by bacteria of the genus Campylobacter. Diphtheria and pertussis (Treatment and Prevention).

Contraindications.

Hypersensitivity to other macrolides or midecamycin, severe liver failure.

Pregnancy and breast-feeding.

Maybe, if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding (It passes into breast milk).

Side effects.

Abdominal pain, anorexia, nausea, vomiting, diarrhea, transient increase in liver transaminases, giperʙiliruʙinemija (in predisposed patients), eozinofilija, allergic skin reactions, hives, stomatitis; very rarely - persistent diarrhea, which may indicate pseudomembranous colitis.

Cooperation.

Together with the admission midecamycin decreases the excretion of cyclosporine and warfarin, biotransformation and carbamazepine alkaloidov sporыnyi.

Dosing and Administration.

Inside (before meals) Adults appoint 400 mg 3 once a day, The maximum daily dose - 1600 mg. In children, the daily dose of 30-50 mg / kg divided into 2, and in severe infections - on 3 admission. Babies weighing up 30 kg (10 years) - By 400 mg 3 fold or 22,5 ml suspension 2 once a day; to 20 kg (6 years) - By 15 ml 2 once a day; to 15 kg (4 year) - By 10 ml 2 once a day; to 10 kg (1-2 Years) - By 7,5 ml 2 once a day; to 5 kg (5 Months) - 3,75 ml 2 once a day. The suspension was shaken before use and is used within no more than 14 days. Duration of treatment - 7-10 days, if chlamydial infection - 14 days.

Precautions.

Prolonged treatment is necessary to monitor liver function, especially in patients with a history of liver disease.

Cooperation