Metaprot: instructions for using the medicine, structure, Contraindications

Active material: Etiltiobenzimidazola hydrobromide
When ATH: A13A
CCF: The drug is a tonic and adaptogenic action
ICD-10 codes (testimony): F07, F07.2, F48.0, G00, G04, I69, T90, Z54, Z73.0, Z73.3
When CSF: 02.14
Manufacturer: Antiviral NPO ZAO (Russia)

Metaprot: dosage form, composition and packaging

Capsules hard gelatin, №3, white housing, cap yellow; contents of capsules – a mixture of powder and granules of white or white with Valium a color shade.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, colorant sunset yellow (E110), quinoline yellow dye (E104), metilparagidroksiʙenzoat, propilparagidroksibenzoat, Titanium dioxide (E171), water.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (5) – packs cardboard.
100 PC. – plastic jars (1) – packs cardboard.

Capsules hard gelatin, №2, white housing, orange cap; contents of capsules – a mixture of powder and granules of white or white with Valium a color shade.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, colorant sunset yellow (E110), metilparagidroksiʙenzoat, propilparagidroksibenzoat, Titanium dioxide (E171), water.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (5) – packs cardboard.
100 PC. – plastic jars (1) – packs cardboard.

Capsules hard gelatin, №3, white housing, cap dark orange; contents of capsules – a mixture of powder and granules of white or white with Valium a color shade.

Excipients: giproloza, colloidal silicon dioxide, lactose, magnesium stearate.

Composition of hard gelatin capsules: gelatin, carmine dye Ponceau 4R (E124), colorant sunset yellow (E110), metilparagidroksiʙenzoat, propilparagidroksibenzoat, Titanium dioxide (E171), water.

10 PC. – packings Valium planimetric (2) – packs cardboard.
10 PC. – packings Valium planimetric (5) – packs cardboard.
100 PC. – plastic jars (1) – packs cardboard.

Metaprot: pharmachologic effect

Preparation with adaptogenic action. It has nootropnoy, antihypoxic, antioxidant and immunomodulatory activity, improves tissue regeneration.

The mechanism of action is the activation of RNA synthesis, then proteins, incl. enzyme and related to the immune system. The activation of the synthesis of enzymes of gluconeogenesis, that provide utilization of lactate (factor a, limiting operation) and resynthesis of carbohydrates – a source of energy during intensive loads, which leads to increased physical performance. Increased synthesis of mitochondrial enzymes and structural proteins of the mitochondria provides increased energy production and maintaining a high degree of coupling of oxidation and phosphorylation. Continued high levels of ATP synthesis deficiency of oxygen helps expressed antihypoxic and antiischemic activity.

It increases synthesis of antioxidant enzymes and has a pronounced antioxidant activity. It increases the body's resistance to the effects of extreme factors – physical exertion, stress, hypoxia, Hyperthermia. Improves performance during exercise.

It possesses strong action antiastenicheskim, accelerates recovery from extreme impacts.

The maximum effect is achieved after 1-2 h after dosing, duration – 4-6 no. Against the background of course taking effect usually grows in the first 3-5 days, then steadily maintained at the current level.

Metaprot: pharmacokinetics

After ingestion well absorbed from the gastrointestinal tract. After a single dose is found in the blood 30 m. With long-term continuous administration of kursovom, especially in high doses, there may be a tendency to accumulation of the drug with an increase in its concentration in the blood to 10-12 Day use.

Extensively metabolized in the liver.

Metaprot: testimony

• increase and recovery of working capacity, incl. in extreme conditions, (Heavy exercise, gipoksiya, overheating);
• adaptation to the impact of various extreme factors;
• asthenic disorders of various nature (neurasthenia, somatic diseases, after serious infections and intoxications, in front of- and postoperative surgical interventions);
• as part of complex therapy for traumatic brain injury, meningitis, Encephalitis, cerebrovascular events, cognitive disorders.

Metaprot: dosing regimen

The drug is prescribed inside, after meal.

Adults appoint 250 mg 2 times / day. If necessary, the daily dose is increased to 750 mg (500 mg in the morning and 250 mg – after lunch), and patients with a body weight above 80 kg – to 1 g (by 500 mg 2 times / day).

A course of treatment – 5 days with 2 day intervals between them in order to avoid accumulation of the drug. The number of courses depends on the effect and averages 2-3 (less often 1 or 4-6) rates.

To improve performance in extreme conditions take medication for 40-60 minutes before the upcoming activity at a dose of 500-750 mg. If you continue to work through the readmission produce 68 h dose 250 mg. The maximum daily dose – 1.5 g, and the next day – 1 g.

To maintaining a high level of efficiency for a long time (few weeks) and for activation of adaptive processes the drug is prescribed under the scheme: 5-day course of a 2-day intervals at a dose 250 mg 2 times / day.

Metaprot: side effects

From the digestive system: discomfort in the stomach and liver; rarely – nausea, vomiting.

Allergic reactions: facial flushing, rhinitis.

CNS: headache.

Metaprot: Contraindications

• gipoglikemiâ;
• expressed human liver;
• epilepsy;
• arterial hypertension;
• glaucoma;
• coronary artery disease;
• Arrhythmia;
• lactase deficiency, Lactose Intolerance, malabsorption of glucose-galactose;
• pregnancy;
• lactation;
• childhood;
• hypersensitivity to the drug.

Metaprot: Pregnancy and lactation

Use of the drug Metaprot^® contraindicated during pregnancy and lactation.

Metaprot: Special instructions

The drug should not be taken in the evening (possible violation of falling asleep).

When adverse reactions necessary to reduce the dose or stop taking the drug.

During treatment with the recommended diet, rich in carbohydrates.

Metaprot: overdose

Symptoms: hypererethism, sleep at night.

Treatment: gastric lavage, administration of activated charcoal, if necessary – simptomaticheskaya therapy.

Metaprot: drug interaction

Inhibitors of microsomal liver enzymes CYP1A2, CYP2C9, CYP2D6, CYP3A4 (eg, cimetidine) can increase the concentration of drug in the blood.

Metaprot^® It enhances the beneficial effects of metabolic drugs (incl. inozina (cm. instructions Groprinosin), nootropics (incl. piracetam), antihypoxic funds (incl. trimetazidine), potassium and magnesium asparaginata, glutamic acid, vitamins (incl. a-токоферол), and antianginal drugs (nitrates, beta-blockers).

Metaprot: terms of dispensing from pharmacies

The drug is released under the prescription.

Metaprot: terms and conditions of storage

List B. The drug should be stored in a dry, protected from light, inaccessible to children at temperature not exceeding 25 ° C. Shelf life – 3 year.