Etiltiobenzimidazola hydrobromide

When ATH:
A13A

Pharmacological action

It has a stimulating effect, It has antihypoxic activity, increases resistance to hypoxia and increases efficiency during exercise. Considered as representative of a new group - actoprotective drugs. The mechanism of action is the activation of RNA and protein synthesis in various cells, including the synthesis of enzyme, structure, and proteins, related to the immune system. It activates the synthesis of enzymes of gluconeogenesis, ensuring the recycling of lactate - factor, limiting availability and resynthesis of carbohydrates - the most important sources of energy in intensive loads, which leads to increased physical performance. Strengthening Education of mitochondrial enzymes and structural proteins of the mitochondria provides increased energy production and maintaining a high degree of coupling of oxidation and phosphorylation. Maintaining a high level of ATP synthesis in the oxygen deficiency contributes to severe antihypoxic and antiischemic activity of the drug. The drug increases the synthesis of antioxidant enzymes and has a pronounced antioxidant activity. After a single dose is found in the blood 30 m, maximum effect is achieved after 1-2 no, duration - 4-6 no. Against the background of course taking effect usually grows in the first 3-5 days, then steadily maintained at the current level.

Pharmacokinetics

It is well absorbed from the gastrointestinal tract after oral administration, actively metabolized in the liver. With long-term continuous administration of kursovom, especially in large doses, there may be a tendency to accumulation of the drug with an increase in its concentration in the blood to 10-12 Day use.

Testimony

Increase and Recovery, including in extreme conditions (Heavy exercise, gipoksiya, overheating. Adapting to the impacts of various extreme factors. Asthenic disorders of different nature (neurasthenia, somatic diseases, after serious infections and intoxications, before- and postoperative surgical interventions). In the combined therapy: craniocerebral injury, meningitis, encephalitis, cerebrovascular accidents, cognitive abnormality.

There is evidence of immunostimulatory effects bemitila and its effectiveness in this regard, in the treatment of certain infectious diseases.

Contraindications

Hypersensitivity.

C care

Severe hepatic impairment (acute viral hepatitis, cirrhosis, toxic lesions). Arterial hypertension, glaucoma, pregnancy, lactation.

Dosage regimen

Inside, after meal, by 0.25 g 2 once a day. If necessary, the daily dose is increased to 0.75 g (0.5 g in the morning and 0.25 g - afternoon), and those weighing in excess of 80 kg - up 1 g (by 0.5 g 2 once a day). A course of treatment - 5 days with 2 day intervals between them in order to avoid accumulation of the drug. The number of courses depends on the effect and averages 2-3 (less often 1 or 4-6) rates. To improve performance in extreme conditions take medication for 40-60 minutes before the upcoming activity at a dose of 0,5-0,75 g. If you continue to work through the readmission produce 68 h dose 0.25 g. The maximum daily dose - 1.5 g, and the next day 1 g. To maintain a high level of performance for a long time (few weeks) and to activate the adaptive processes the drug is prescribed under the scheme: 5-day course of a 2-day intervals at a dose 0.25 g 2 once a day.

Side effect

Discomfort in the epigastric and right upper quadrant, nausea, vomiting, facial flushing, rhinitis, headache (In these cases, reduce the dose or stop taking the drug). If you exceed the recommended doses or prolonged use of the drug without interruption cumulative effect is possible with the development of excessive stimulating effect, including arousal, sleep disturbance.

Cautions

Do not prescribe in the evening in connection with possible violations of sleep. While receiving the drug recommended diet, rich in carbohydrates.

Drug Interactions

Inhibitors of microsomal oxidation (cimetidine) can increase the concentration of drug in the blood. Etiltiobenzimidazol enhances the positive effects of metabolic drugs, including nootropic drugs (including piracetam), antioxidants (including alpha-tocopherol), antigipoksantov (including trimetazidine), non-steroidal anabolic drugs (riʙoksin), potassium and magnesium asparaginata, glutamic acid, vitamins, and antianginal drugs (nitrates, beta-blockers).