Metamizole

When ATH:
N02BB02

Characteristic.

White or white with a barely noticeable yellowish white crystalline powder, in the presence of moisture is rapidly degraded. Easily soluble in water (1:1,5), water solution It has a pH 6-7,5. It is soluble in ethanol (1:60–1:80), practically insoluble in ether, xloroforme, acetone.

Pharmacological action.
Anti-inflammatory, analgesic, pyretic.

Application.

Arthralgia, rheumatism, xoreja, pain: headache, Toothbrush, Menstrual, neuralgia, işialgija, myalgia, colic (renal, hepatic, E.), pulmonary infarction, myocardial infarction, dissecting aortic aneurysm, thrombosis of major vessels, inflammatory (pleurisy, pneumonia, lyumbago, miokardit), injuries, burns, decompression sickness, shingles, tumors, orchitis, pancreato, peritonitis, esophageal perforation, pneumothorax, post-transfusion complications, priapism; feverish syndrome in acute infectious, purulent and urological diseases (prostatitis), insect bites (incl. Mosquitoes, Bees, tics).

Contraindications.

Hypersensitivity, inhibition of hematopoiesis (agranulocytosis, cytostatic or infectious neutropenia), severe liver or kidney disease, prostaglandin asthma, nasledstvennaya gemoliticheskaya anemia, associated with deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation.

Side effects.

Granulocytopenia, agranulocytosis, thrombocytopenia, gemorragii, hypotension, interstitial nephritis, allergic reactions (incl. sindromy Stevens-Johnson, Layella, bronchospasm, anaphylactic shock).

Cooperation.

Effect increase barbiturates, codeine, H₂-antihistamines, propranolol (slow inactivation). Sarkolizin tiamazol and increase the likelihood of leucopenia. Increases hypoglycemic activity of oral antidiabetic drugs (releases from binding with blood proteins), sedative - alcohol, reduces the concentration of cyclosporine in plasma.

Overdose.

Symptoms: gipotermiя, severe hypotension, heartbeat, breathlessness, noise in ears, nausea, vomiting, weakness, drowsiness, delirium, disturbance of consciousness, convulsions; possible development of acute agranulocytosis, hemorrhagic syndrome, acute renal and hepatic insufficiency.

Treatment: induction of vomiting, chreszondovoe gastric lavage, appointment of laxatives, activated carbon and conduct forced diuresis, alkalization of blood, simptomaticheskaya therapy, aimed at maintaining vital functions.

Dosing and Administration.

/ M or I / (with strong pains) - 1-2 ml 50% or 25% solution 2-3 times / day, the maximum daily dose 2 g; Children are at 0.1-0.5 ml. Inside after eating or rectally 250-500 mg 2-3 times / day, The maximum single dose - 1 g, daily - 3 g. The usual dose for children 2-3 years - 50-100 mg, 4-5 Years - 100-200 mg, 6-7 years - 200 mg, 8-14 Years - 250-300 mg 2-3 times / day.

Precautions.

Requires medical supervision (high frequency of allergic reactions, incl. fatal, particularly when administered parenterally). Not recommended regular long-term use due to myelotoxicity. It eliminates the use to relieve acute pain in the abdomen (to determine the cause). In appointing the patients with severe cardiovascular disease should be carefully monitored for hemodynamics. To use caution in patients with SBP below 100 mm Hg. Art., with a history of kidney disease, indications of (pyelonephritis, glomerulonephritis) and long-term history of alcohol.

Cautions.

When using Metamizole possible red color of urine by excretion of metabolites.

Cooperation