Mesalazine

When ATH:
A07EC02

Pharmacological action.
Anti-inflammatory.

Application.

Inflammatory bowel disease (nespetsificheskiy yazvennыy colitis, Crohn's disease), in the acute phase and prevention their recurrence.

Contraindications.

Hypersensitivity (incl. other derivatives of salicylic acid), expressed human liver and kidneys, blood disease, gyemorragichyeskii diatyez, gastric ulcer and duodenal ulcer, pregnancy, lactation, infancy (to 2 years).

Side effects.

Discomfort, abdominal pains, nausea, flatulence, frequent urge to defecate, aggravation of hemorrhoids, hyperthermia, flu-like syndrome and acute intolerance (gripes, bloody flux, fever, headache, rash), asthenia, drug lupus syndrome, artralgii, alopecia, metgemoglobinemiâ, transaminase elevation, alkaline phosphatase, creatinine, BUN, allergic skin rashes.

Cooperation.

Enhances ulzerogennosti glucocorticoids, the toxicity of methotrexate, hypoglycemic effect of sulfonylureas, гипопротромбинемический — антикоагулянтов. It slows down the absorption of cyanocobalamin. It weakens the activity of furosemide, spironolactone, rifampicin.

Dosing and Administration.

Inside, without chewing, drinking plenty of water: взрослым при обострении — по 1 g 4 once a day, поддерживающие дозы — 500 mg 3 раза в сутки при неспецифическом язвенном колите и по 1 g 4 twice daily for Crohn's disease; детям старше 2-х лет — 20–30 мг/кг/сут в несколько приемов. При тяжелом течении заболевания суточная доза может быть увеличена до 3–4 г, but no more than 8-12 weeks. Rectal (After emptying the rectum): if proctitis, proctosigmoiditis and left-sided ulcerative colitis for adults 1 supp. 1-2 Times a day. В виде лекарственной микроклизмы — 60 г суспензии 1 once a day, before bedtime.

Precautions.

Before, during (1-2 Times per month), and after treatment (every 3 Months) should control the peripheral blood, the level of urea, creatinine, general urine analysis. If you suspect an acute intolerance syndrome development mesalazine should be abolished. However, it should be taken into account, acute intolerance syndrome that in some cases it can be difficult to differentiate from a severe exacerbation of inflammatory bowel disease.

Cooperation