Memantine

When ATH:
N06DX01

Characteristic.

A derivative of amantadine.

Pharmacological action.
Neuroprotective, antispasticheskoe, antiparkinsonian.

Application.

Dementia (Alzheimer type, Cardiovascular, Mixed dementia of all severities); dysfunction of the central nervous system of mild to moderate severity (weakening of memory and ability to concentrate, loss of interest in activities, fatigue, limiting the ability to take care of themselves); Cerebral and spinal spastic syndrome (as a result of traumatic brain injury, multiple sclerosis, stroke), Parkinson's disease, parkinsonizm.

Contraindications.

Hypersensitivity, confusion, expressed by the human kidney.

Restrictions apply.

Epilepsy, thyrotoxicosis, pregnancy, lactation.

Pregnancy and breast-feeding.

Be wary of pregnancy (sufficient experience of use during pregnancy is not) and breastfeeding (no data on the penetration of breast milk).

Side effects.

From the nervous system and sensory organs: dizziness, internal or restlessness, hypererethism, fatigue, intracranial hypertension.

Other: nausea.

Cooperation.

It enhances the effect of barbiturates, neuroleptics, anticholinergics, levodopa, dopamine receptor agonists (bromocriptine, and others.), amantadina. It may change the effect of dantrolene and baclofen.

Dosing and Administration.

Inside, while eating. The mode set individually, treatment is recommended to start with the lowest effective dose. Adults: the initial dose - 5 mg / day, If necessary dose can be downloads raise 5 mg, supporting dose is 10-20 mg/day (up to 30-60 mg/day). Patients with renal impairment should be administered in smaller doses. Babies - 0,5 mg/kg/day, or based 1 drop on 1 kg body weight.

Precautions.

If the kidney function Treatment should be under the control of their function. Be wary of during the drivers of vehicles and people, skills relate to the high concentration of attention.

Cooperation

Active substanceDescription of interaction
AmantadinFMR: synergism. Strengthens (mutually) antiparkinsonian effect.
BromocriptineFMR: synergism. Strengthens (mutually) antiparkinsonian effect.

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