LOMEKSIN

Active material: Fentykonazol
When ATH: G01AF12
CCF: The drug with the antifungal activity for topical application in gynecology
ICD-10 codes (testimony): A59, B37.3
When CSF: 08.03.01
Manufacturer: Recordati Industria Chimica e Farmaceutica S.p.A.. (Italy)

Pharmaceutical form, composition and packaging

Vaginal Cream 2% white or nearly white, uniform.

Excipients: propylene glycol, Nipple gidrogyenizirovannyi, almond oil, cetyl alcohol, glycerol monostearate, sodium edetate, polyglycol ester of fatty acids, Purified water.

30 g – aluminum tuba (1) – packs cardboard.

Pharmacological action

Antifungal drug broad-spectrum topical. Fenticonazole is a synthetic derivative of imidazole (its racemic mixture in the form of nitrate salt fenticonazole). It provides local fungicidal and fungistatic. Also has anti-bacterial and anti-inflammatory action. The mechanism of action is to inhibit the synthesis of ergosterol, regulating the permeability of the cell membrane of fungi.

It is active against дрожжевых грибов Candida spp. (including Candida albicans) and gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as against Trichomonas vaginalis.

Unlike other known azole compounds (in particular, econazole, miconazole, and ketoconazole) фентиконазол ингибирует биосинтез протеаз Candida spp.

At concentrations below the MIC – from 0.25 to 16 ug / ml. This action does not depend on the value of antimycotic activity and due to the inhibition of one of the stages of the formation of proteolytic enzymes, yeast-like fungi.

Pharmacokinetics

Fenticonazole hardly exposed systemic absorption, prolonged topical application, its concentration in the blood is not defined. The extent of absorption of the mucous membranes is extremely low

Testimony

- Vulvovaginal candidiasis;

- Vaginalinyi trichomoniasis.

Dosage regimen

Vaginal Cream 2% injected deep into the vagina (about 5 g) 1 time / day in the evening, before bedtime, if necessary – 2 times / day, in the morning and in the evening.

Treatment is carried out to full clinical recovery, usually 3-6 days.

Side effect

Allergic reactions: rarely – hives, rash, эritema.

Local reactions: burning, itch, Local irritation.

Lomeksin, usually, well tolerated, side effects are transient and do not require discontinuation of the drug.

Contraindications

- I trimester of pregnancy;

- Hypersensitivity to the drug.

Pregnancy and lactation

Currently, data on the efficacy and safety of Lomeksina during pregnancy and lactation (breast-feeding) no. Use of the drug in the I trimester of pregnancy is contraindicated.

Cautions

Prolonged use of the drug may develop sensitization. In this case, you need to stop treatment, and the patient should contact your doctor.

If no effect for 3 weeks of therapy, treatment should be discontinued, and specify the diagnosis.

The drug should not be prescribed during menstruation. The course of treatment it is advisable to start after menstruation.

To prevent reinfection to simultaneously treat a partner cream, which is applied to the glans penis and foreskin.

Overdose

Currently, cases of drug overdose were reported Lomeksin.

Drug Interactions

Drug interactions or drug Lomeksin incompatibility with other drugs not described.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children at temperature from 15 ° to 25 ° C, away from open flame. Shelf life – 3 year.