Fentykonazol

When ATH:
G01AF12

Pharmacological action

Antifungal, imidazole. It inhibits the synthesis of ergosterol, breaking the permeability of the cell wall of the fungus.

It is active against Candida spp. (including Candida albicans) and gram-positive bacteria (Staphylococcus aureus, Streptococcus spp.), as well as against Trichomonas vaginalis.

Unlike other known azole compounds inhibit the biosynthesis of protease fenticonazole Candida spp. at concentrations below the minimum inhibitory – from 0.25 to 16 ug / ml. This action does not depend on the value of antimycotic activity and due to the inhibition of one of the stages of the formation of proteolytic enzymes, yeast-like fungi.

Pharmacokinetics

Virtually no exposed systemic absorption. The degree of absorption through the mucous membranes of the extremely small.

Testimony

Vulvovagnialny candidiasis, vaginalinyi trichomoniasis.

Dosage regimen

Apply intravaginally 1-2 times / day for 3-6 days. The dosage depends on the dosage form.

Side effect

Allergic reactions: rarely – hives, rash, эritema.

Local reactions: possible burning, itch, Local irritation.

Contraindications

I trimester of pregnancy, Hypersensitivity to the drug.

Pregnancy and lactation

The use in the I trimester of pregnancy is contraindicated.

Currently, data on the efficacy and safety of fenticonazole in II and III trimesters of pregnancy and lactation is not available

Cautions

With prolonged use may develop sensitization.

Do not use during menstruation. The course of treatment it is advisable to start after menstruation.

To prevent reinfection to the simultaneous treatment of sexual partners.

Drug Interactions

The data is not provided.