KOMBILIPEN

Active material: Combined multivitamin preparation
When ATH: A11AB
CCF: The complex B vitamins
ICD-10 codes (testimony): G50.0, G51, G62.1, G63.2, M54.1, M54.3, M54.4
When CSF: 02.11.01
Manufacturer: OAO Pharmstandard-UfaVITA (Russia)

Pharmaceutical form, composition and packaging

The solution for the / m clear, pinkish-red color and odor.

Excipients: benzyl alcohol, sodium tripolyphosphate, Sodium Phosphate, potassium ferrocyanide, Sodium hydroxide, water d / and.

2 ml – vials of dark glass (5) – packs cardboard.
2 ml – vials of dark glass (10) – packs cardboard.

Pharmacological action

Combined multivitamin preparation. Effect of the drug is determined by the properties of vitamins, its constituent.

Thiamine Hydrochloride (vitamin B₁) participates in the nerve impulse.

Pyridoxine hydrochloride (vitamin B₆) It has a vital impact on the metabolism of proteins, carbohydrates and fats, It is necessary for normal hematopoiesis, functioning of the CNS and peripheral nervous system. It provides synaptic transmission, inhibitory processes in the CNS, involved in the transport of sphingosine, a member of the nerve sheath, involved in the synthesis of catecholamines.

Цianokoʙalamin (vitamin B₁₂) involved in the synthesis of nucleotides, It is an important factor for normal growth, blood formation and development of epithelial cells; necessary for the metabolism of folic acid and synthesizing myelin.

Pharmacokinetics

Data on the pharmacokinetics Combilipen missing.

Testimony

In the complex treatment of these neurological diseases:

- Neuralgia nerve troynichnogo;

- Neuritis of the facial nerve;

- Pain, caused by diseases of the spine (mezhrebernaya neuralgia, ljumʙoişialgija, lumbar syndrome, cervical syndrome, neck and shoulder syndrome, radicular syndrome, caused by degenerative changes of the spine);

- Polyneuropathy of different etiologies (Diabetic, Alcoholic).

Dosage regimen

The drug is introduced into / m.

When symptom relief appoint 2 ml daily for 5-7 days, then 2 ml 2-3 times / week. during 2 weeks; in mild cases – by 2 ml 2-3 times / week. 7-10 days.

The duration is determined by the physician individually depending on the severity of symptoms, but should not exceed 2 weeks.

For maintenance therapy is recommended to take oral forms of B vitamins.

Side effect

Allergic reactions: itching, hives, labored breathing, angioedema, anaphylactic shock.

Other: increased perspiration, tachycardia, acne.

Contraindications

- Severe and acute forms of decompensated heart failure;

- Pregnancy;

- Lactation (breast-feeding);

- Hypersensitivity to the drug.

Pregnancy and lactation

The drug is contraindicated during pregnancy and lactation (breast-feeding).

Cautions

Combilipen contains benzyl alcohol. It can not be used in children because of the content in the preparation of benzyl alcohol.

Overdose

Symptoms: increased symptoms of side effects of the drug.

Treatment: simptomaticheskaya therapy.

Drug Interactions

Thiamine decomposes completely in solutions, containing sulfites.

Thiamine is incompatible with oxidizing and reducing substances: mercuric chloride, iodide, karʙonatom, acetate, tannic acid, hardware-ammonium citrate, and sodium pentobarbital, riʙoflavinom, benzilpenicillinom, dextrose and sodium metabisulphite.

Copper accelerates the destruction of thiamine; Besides, thiamine loses its effect by increasing the pH (more 3).

Levodopa reduces the effects of therapeutic doses of vitamin B₆.

Vitamin B₁₂ incompatible with salts of heavy metals.

Conditions of supply of pharmacies

The drug is released under the prescription.

Conditions and terms

The drug should be stored out of reach of children, protected from light, at a temperature of from 2 ° to 8 ° C.. Shelf life – 2 year.