Active material: Clotrimazolum
When ATH: D01AC01
CCF: Antifungal agents for external use
When CSF: 08.02.01
Manufacturer: HYPERION S.A. (Romania)
◊ 1% in the form of a homogeneous mass of white to yellowish white.
| 1 g | |
| clotrimazole | 10 mg |
Excipients: cetyl alcohol, vaseline, glycerol, Tween-80, nipagin, water distillirovannaya.
20 г – тубы алюминиевые (1) – пачки картонные.
Antifungal groups imidazole derivatives for topical use. It has action by disrupting the synthesis of ergosterol, which is part of the cell membrane of fungi. It has a broad spectrum of action.
It is active against dermatophytes, molds, fungi of the genus Candida, Malassezia furfur.
Clotrimazole is also active against Corynebacterium minutissimum, Streptococcus spp., Staphylococcus spp., Trichomonas vaginalis.
When applied topically clotrimazole well into the different layers of the skin, achieving therapeutic concentrations. When applied topically clotrimazole minor amount absorbed into the blood.
Fungal skin and mucous membranes, caused by dermatophytes, molds and yeast-like fungi, pityriasis versicolor, erythrasma, vulvovaginal candidiasis, trichomoniasis, fungal infections, complicated by secondary pyoderma.
When applied topically applied to the affected skin 2-3 times / day for 2-4 weeks.
When oral use 1-2 times / day max 7 days.
Интравагинально – по 100-500 mg for 1-6 days.
Local reactions: allergic contact dermatitis, redness, burning sensation.
Hypersensitivity to clotrimazole, I trimester of pregnancy.
IN experimental studies found, that when used in high doses, clotrimazole has fetotoxic effects.
Unknown, whether clotrimazole allocated with breast milk. Although clotrimazole is not contraindicated during pregnancy and lactation, It should take into account the potential risk in the choice of antifungal therapy.
Formulations, intended for intravaginal use, not used during menstruation.
To prevent reinfection should be simultaneous treatment of sexual partners. Clotrimazole is not recommended for use in ophthalmology.
While the use of amphotericin B, nystatin clotrimazole reduced activity.
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