XOLISAL

Active material: Choline salicylate + Tsetalkoniya chloride
When ATH: A01AD11
CCF: The preparation with antimicrobial, anti-inflammatory and analgesic action for local application in dentistry
Codes ICD-10 (testimony): B37.0, K00.7, K05, K12, L43, L51.1, Z51.4
When CSF: 25.03
Manufacturer: PHARMACEUTICAL WORKS JELFA S.A. (Poland)

Pharmaceutical form, composition and packaging

◊ Dental Gel as a colorless, clear, a homogeneous mass with the smell of anise oil.

Excipients: hydroxyethyl, glycerol, metilparagidroksiʙenzoat, propilparagidroksibenzoat, anise oil, ethanol, Purified water.

10 g – aluminum tuba (1) – packs cardboard.

Pharmacological action

Combined preparation for local use in dentistry with antimicrobial, antiinflammatory and analgesic action.

When applied topically, choline salicylate is rapidly absorbed oral mucosa, providing local anesthetic, anti-inflammatory and antipyretic effect. Inhibits the activity of COX, the function of macrophages and neutrophils, production of interleukin-1 and inhibits the synthesis of prostaglandins. Also possesses antimicrobial and antifungal activity in acidic and alkaline medium.

Tsetalkoniya chloride – antiseptic, acts on bacteria, fungi and viruses.

Gel ethanol-adhesive backing enables the rapid development of long-term effect and keeps the mucous membrane of the active substances.

Analgesic effect occurs within 2-3 m, while it lasts 2-8 no.

Xolisal^® no sugar, It does not have locally irritating and is well tolerated by patients.

Pharmacokinetics

When applied to the mucous membranes is well absorbed.

Testimony

For topical administration to the oral mucosa as an analgesic and anti-inflammatory agent in the treatment of periodontal diseases, mucosal, Diseases, proceeding with an inflammatory response and pain:

- Stomatitis of various etiologies;

- Gingivitis;

- Periodontitis;

- Damage to the mucous membranes of the mouth when wearing dentures;

- Injuries of the oral mucosa;

- The pain of teething in children;

- Cheilitis;

- Oral candidiasis;

- Minor surgery;

- Lichen planus;

- As part of combination therapy for exudative erythema multiforme (incl. at Stevens-Johnson syndrome).

Dosage regimen

Xolisal^® used topically 2-3 times / day before meals (with the aim of anesthesia) or after meals and at bedtime. The strip of gel length 1 cm Adult and 0.5 cm children extruded onto a clean finger and rub with light massaging movements in the affected area of ​​the oral mucosa.

At periodontal diseases Gel should be laid in the gingival pockets, and apply as a compress or gently rubbed into the gums 1-2 times / day.

Side effect

Local reactions: transient burning sensation at the site of drug application, passing on their own.

Other: allergic reactions.

Contraindications

- Hypersensitivity to the drug;

- Hypersensitivity to salicylates.

FROM caution the drug should be used during pregnancy, lactation and children under 1 year.

Pregnancy and lactation

It should be used with caution Holisal^® Pregnancy and lactation.

Cautions

At the first signs of side effects, patients should immediately contact your doctor.

The drug should be used only for external use.

Use in Pediatrics

Precautions should use the drug in children aged 1 year.

Effects on ability to drive vehicles and management mechanisms

The drug does not limit the psycho-physical activity, the ability to drive vehicles and maintenance of moving mechanisms.

Overdose

Due to the low systemic absorption of active substances, members of the drug Holisal^®, overdose is unlikely.

Drug Interactions

When using Holisal^® doses, greatly exceeding recommended, may increase the effects of other anti-inflammatory used simultaneously, antipyretics and analgesics.

Conditions of supply of pharmacies

The drug is resolved to application as an agent Valium holidays.

Conditions and terms

The drug should be stored out of reach of children at or above 25 ° C; Do not freeze. Shelf life – 3 year.